{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:32:43Z","timestamp":1787016763556,"version":"build-2736575974"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Pfizer Inc. | Pfizer Pharmaceuticals"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2023,12,14]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We performed\n                    <jats:italic>in vitro<\/jats:italic>\n                    antifungal susceptibility testing of manogepix against the yeast phase of 78\n                    <jats:italic>Emergomyces africanus<\/jats:italic>\n                    , 2\n                    <jats:italic>Emergomyces pasteurianus,<\/jats:italic>\n                    and 5\n                    <jats:italic>Blastomyces emzantsi<\/jats:italic>\n                    isolates using a reference broth microdilution method following Clinical and Laboratory Standards Institute recommendations. All three pathogens had low minimum inhibitory concentrations ranging from &lt;0.0005 to 0.008 mg\/L. Manogepix should be investigated in animal models and potentially in future human clinical trials for endemic mycoses.\n                  <\/jats:p>","DOI":"10.1128\/aac.01104-23","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T09:00:35Z","timestamp":1700125235000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["<i>In vitro<\/i>\n                    manogepix susceptibility testing of South African\n                    <i>Emergomyces africanus, Emergomyces pasteurianus<\/i>\n                    , and\n                    <i>Blastomyces emzantsi<\/i>\n                    clinical isolates"],"prefix":"10.1128","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2618-8630","authenticated-orcid":false,"given":"Silondiwe P.","family":"Nzimande","sequence":"first","affiliation":[{"name":"National Institute for Communicable Diseases (NICD), a Division of the National Health Laboratory Service, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-9462","authenticated-orcid":false,"given":"Nelesh P.","family":"Govender","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Diseases (NICD), a Division of the National Health Laboratory Service, Johannesburg, South Africa"},{"name":"School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Witwatersrand, South Africa"},{"name":"Division of Medical Microbiology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6117-4309","authenticated-orcid":false,"given":"Tsidiso G.","family":"Maphanga","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Diseases (NICD), a Division of the National Health Laboratory Service, Johannesburg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40588-016-0034-6"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215460"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00191-2"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R700002-JLR200"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02319-17"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01715-18"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01611-0"},{"key":"e_1_3_1_9_2","first-page":"6","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard","author":"Wayne P","year":"2008","unstructured":"Wayne P, Clinical and laboratory standards Institute. 2008. CLSI document M27-A3 and supplement, p 6\u201312. In Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02524-16"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01419-22"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02347-22"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02476-20"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01795-20"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00178-20"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01735-19"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01661-19"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01623-22"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01104-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01104-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T09:07:43Z","timestamp":1702544863000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.01104-23"}},"subtitle":[],"editor":[{"given":"Andreas H.","family":"Groll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,12,14]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12,14]]}},"alternative-id":["10.1128\/aac.01104-23"],"URL":"https:\/\/doi.org\/10.1128\/aac.01104-23","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,14]]},"assertion":[{"value":"2023-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01104-23"}}