{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:00:44Z","timestamp":1788454844095,"version":"build-2803163510"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,4,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Amikacin is frequently used for the treatment of neonatal sepsis. The Dutch Pediatric Formulary recommends a complex pharmacokinetic (PK) model-derived dosing regimen, which consists of dosing categories based on postnatal age and weight that results in adequate PK\/pharmacodynamic (PK\/PD) target attainment. However, a simplified dosing regimen may be easier to apply in clinical practice. We evaluated PK\/PD target attainment of amikacin in neonates using this simplified or complex dosing regimen. This retrospective cohort study included neonates with routinely measured amikacin concentrations at the neonatal intensive care units of the Amsterdam University Medical Center (simplified dosing regimen) or University Hospitals Leuven (complex dosing regimen). Peak (C\n              <jats:sub>max<\/jats:sub>\n              ) and trough (C\n              <jats:sub>min<\/jats:sub>\n              ) concentrations and the area under the concentration-time curve (AUC) for the first dosing interval were calculated by Bayesian estimation for both populations. Targets of C\n              <jats:sub>max<\/jats:sub>\n              (\u226515, \u226525, and \u226535 mg\/L), C\n              <jats:sub>min<\/jats:sub>\n              (\u22643 and \u22645 mg\/L), and AUC\/minimal inhibitory concentration (MIC: 2, 4, and 8 mg\/L for\n              <jats:italic>Enterobacterales<\/jats:italic>\n              species) for bacteriostasis and 1-log reduction were evaluated. A target attainment of \u226590% was considered adequate. In total, 366 neonates (768 concentrations) and 579 neonates (1,195 concentrations) received the simplified and complex dosing regimen, respectively. Both regimens achieved target attainment of 100% for C\n              <jats:sub>max<\/jats:sub>\n              \u2265 15 mg\/L, C\n              <jats:sub>min<\/jats:sub>\n              \u2264 5 mg\/L, AUC\/MIC for bacteriostasis, and AUC\/MIC for 1-log reduction up to a MIC of 2 mg\/L. Target attainment was achieved for less stringent targets (C\n              <jats:sub>max<\/jats:sub>\n              \u2265 15 mg\/L, C\n              <jats:sub>min<\/jats:sub>\n              \u2264 5 mg\/L, and AUC\/MIC for bacteriostasis) with the simplified and complex amikacin dosing regimen. Clinicians can choose one of both dosing regimens, depending on their local circumstances, and the availability of integrated (electronic) prescription tools.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.01118-24","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T13:03:56Z","timestamp":1741698236000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Amikacin dosing in neonates: evaluation of target attainment using a simplified and complex pharmacokinetic model-derived dosing regimen in clinical practice"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2600-1381","authenticated-orcid":true,"given":"Marlotte A. A.","family":"van der Veer","sequence":"first","affiliation":[{"name":"Department of Pharmacy & Clinical Pharmacology, Amsterdam University Medical Center","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Smits","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, University Hospitals Leuven","place":["Leuven, Belgium"]},{"name":"Department of Development and Regeneration, KU Leuven","place":["Leuven, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo R.","family":"de Haan","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Emma Children\u2019s Hospital, Amsterdam University Medical Center","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda G. W.","family":"Franken","sequence":"additional","affiliation":[{"name":"Department of Pharmacy & Clinical Pharmacology, Amsterdam University Medical Center","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton H.","family":"van Kaam","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Emma Children\u2019s Hospital, Amsterdam University Medical Center","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caspar J.","family":"Hodiamont","sequence":"additional","affiliation":[{"name":"Medical Microbiology, Amsterdam University Medical Center","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuma A.","family":"Bijleveld","sequence":"additional","affiliation":[{"name":"Department of Pharmacy & Clinical Pharmacology, Amsterdam University Medical Center","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Allegaert","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, University Hospitals Leuven","place":["Leuven, Belgium"]},{"name":"Department of Development and Regeneration, KU Leuven","place":["Leuven, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron A. A.","family":"Math\u00f4t","sequence":"additional","affiliation":[{"name":"Department of Pharmacy & Clinical Pharmacology, Amsterdam University Medical Center","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-021-00465-z"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/11595640-000000000-00000"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15697"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02260.x"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000014053"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13016"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0637-4"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","unstructured":"Formulary DP. 2023. Amikacin. 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Amikacine. Available from: https:\/\/tdm-monografie.org\/amikacine\/. Retrieved 25 Feb 2024."},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200948020-00001"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01118-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01118-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T05:33:25Z","timestamp":1743744805000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.01118-24"}},"subtitle":[],"editor":[{"given":"James E.","family":"Leggett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,4,2]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,2]]}},"alternative-id":["10.1128\/aac.01118-24"],"URL":"https:\/\/doi.org\/10.1128\/aac.01118-24","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,2]]},"assertion":[{"value":"2024-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01118-24"}}