{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:57:23Z","timestamp":1760385443194},"reference-count":16,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We evaluated the\n            <jats:italic>in vitro<\/jats:italic>\n            activity of various antimicrobials alone and in combination against 291 extended-spectrum-\u03b2-lactamase-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n            (ESBL-EC) isolates causing bacteremia in South Korean hospitals. Ceftazidime, cefepime, and piperacillin-tazobactam in combination with amikacin showed greater activity than found in combination with ciprofloxacin. In settings with a high prevalence of ESBL-producing pathogens, combination aminoglycoside antimicrobial therapy, especially with amikacin, may be considered for empirical therapy against suspected Gram-negative sepsis as a carbapenem-saving strategy.\n          <\/jats:p>","DOI":"10.1128\/aac.01121-15","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T22:44:58Z","timestamp":1435617898000},"page":"5834-5837","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["<i>In Vitro<\/i>\n            Activities of 21 Antimicrobial Agents Alone and in Combination with Aminoglycosides or Fluoroquinolones against Extended-Spectrum-\u03b2-Lactamase-Producing Escherichia coli Isolates Causing Bacteremia"],"prefix":"10.1128","volume":"59","author":[{"given":"Min Kyeong","family":"Cha","sequence":"first","affiliation":[{"name":"Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol-In","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, South Korea"},{"name":"Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Eun","family":"Ha","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Mi","family":"Wi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doo Ryeon","family":"Chung","sequence":"additional","affiliation":[{"name":"Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, South Korea"},{"name":"Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyong Ran","family":"Peck","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Hoon","family":"Song","sequence":"additional","affiliation":[{"name":"Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, South Korea"},{"name":"Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Korean Network for Study on Infectious Diseases 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