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The aggregated protein dye YAT2150 has been found to be a potent antileishmanial compound, with a half-maximal inhibitory concentration (IC\n              <jats:sub>50<\/jats:sub>\n              ) of approximately 0.5 \u00b5M against promastigote and amastigote stages of\n              <jats:italic>Leishmania infantum<\/jats:italic>\n              . The encapsulation in liposomes of YAT2150 significantly improved its\n              <jats:italic>in vitro<\/jats:italic>\n              IC\n              <jats:sub>50<\/jats:sub>\n              to 0.37 and 0.19 \u00b5M in promastigotes and amastigotes, respectively, and increased the half-maximal cytotoxic concentration in human umbilical vein endothelial cells to &gt;50 \u00b5M. YAT2150 became strongly fluorescent when binding intracellular protein deposits in\n              <jats:italic>Leishmania<\/jats:italic>\n              cells. This fluorescence pattern aligns with the proposed mode of action of this drug in the malaria parasite\n              <jats:italic>Plasmodium falciparum<\/jats:italic>\n              , the inhibition of protein aggregation. In\n              <jats:italic>Leishmania major<\/jats:italic>\n              , YAT2150 rapidly reduced ATP levels, suggesting an alternative antileishmanial mechanism. To the best of our knowledge, this first-in-class compound is the only one described so far having significant activity against both\n              <jats:italic>Plasmodium<\/jats:italic>\n              and\n              <jats:italic>Leishmania<\/jats:italic>\n              , thus being a potential drug for the treatment of co-infections of both parasites.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.01127-23","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T14:01:29Z","timestamp":1707832889000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Effect of the aggregated protein dye YAT2150 on\n            <i>Leishmania<\/i>\n            parasite viability"],"prefix":"10.1128","volume":"68","author":[{"given":"Luc\u00eda","family":"Rom\u00e1n-\u00c1lamo","sequence":"first","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal), 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