{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:46:46Z","timestamp":1792457206202,"version":"4.5.0"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2024,2,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Manogepix is a potent new antifungal agent targeting the fungal Gwt1 enzyme. Manogepix has previously demonstrated potent\n                    <jats:italic>in vitro<\/jats:italic>\n                    activity against clinical isolates of both\n                    <jats:italic>Candida<\/jats:italic>\n                    (except\n                    <jats:italic>Candida krusei<\/jats:italic>\n                    ) and\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    species. This study determined the\n                    <jats:italic>in vitro<\/jats:italic>\n                    activity of manogepix and comparators against a large collection of infrequently encountered yeast and molds. Manogepix demonstrated potent\n                    <jats:italic>in vitro<\/jats:italic>\n                    activity against infrequently encountered yeasts exhibiting elevated MIC values to other drug classes, including\n                    <jats:italic>Candida<\/jats:italic>\n                    spp. (MIC\n                    <jats:sub>50\/90<\/jats:sub>\n                    , 0.008\/0.12 mg\/L),\n                    <jats:italic>Saprochaete clavata<\/jats:italic>\n                    (\n                    <jats:italic>Magnusiomyces clavatus<\/jats:italic>\n                    ) (MIC\n                    <jats:sub>50\/90<\/jats:sub>\n                    , 0.03\/0.06 mg\/L),\n                    <jats:italic>Magnusiomyces capitatus<\/jats:italic>\n                    (MIC\n                    <jats:sub>range<\/jats:sub>\n                    , 0.016-0.06 mg\/L),\n                    <jats:italic>Rhodotorula minuta<\/jats:italic>\n                    (MIC, 0.016 mg\/L), and\n                    <jats:italic>Rhodotorula mucilaginosa<\/jats:italic>\n                    (MIC\n                    <jats:sub>50\/90<\/jats:sub>\n                    , 0.03\/0.12 mg\/L). Similarly, manogepix was active against infrequently encountered mold isolates and strains exhibiting elevated MIC\/MEC values to echinocandins, azoles, and amphotericin B, including\n                    <jats:italic>Coprinopsis cinerea<\/jats:italic>\n                    (MEC, 0.004 mg\/L),\n                    <jats:italic>Fusarium<\/jats:italic>\n                    spp. (MEC\n                    <jats:sub>50\/90<\/jats:sub>\n                    , 0.016\/0.06 mg\/L),\n                    <jats:italic>Fusarium<\/jats:italic>\n                    (\n                    <jats:italic>Gibberella<\/jats:italic>\n                    )\n                    <jats:italic>fujikuroi<\/jats:italic>\n                    species complex (MEC\n                    <jats:sub>50\/90<\/jats:sub>\n                    , 0.016\/0.03 mg\/L),\n                    <jats:italic>Lomentospora prolificans<\/jats:italic>\n                    (MEC\n                    <jats:sub>50\/90<\/jats:sub>\n                    , 0.03\/0.06 mg\/L),\n                    <jats:italic>Microascus cirrosus<\/jats:italic>\n                    (MEC, 0.008 mg\/L),\n                    <jats:italic>Paecilomyces<\/jats:italic>\n                    spp. (MEC\n                    <jats:sub>50\/90<\/jats:sub>\n                    , \u22640.008\/0.016 mg\/L),\n                    <jats:italic>Pleurostomophora richardsiae<\/jats:italic>\n                    (MEC, 0.06 mg\/L),\n                    <jats:italic>Sarocladium kiliense<\/jats:italic>\n                    (MEC range, 0.016\u20130.12 mg\/L), and\n                    <jats:italic>Scedosporium<\/jats:italic>\n                    spp. (MEC\n                    <jats:sub>50\/90<\/jats:sub>\n                    , 0.03\/0.06 mg\/L). Manogepix demonstrated potent activity against a majority of the infrequently encountered yeast and mold isolates tested including strains with elevated MIC\/MEC values to other drug classes. Additional clinical development of manogepix (fosmanogepix) in difficult-to-treat, resistant fungal infections is warranted.\n                  <\/jats:p>","DOI":"10.1128\/aac.01132-23","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T09:01:16Z","timestamp":1704963676000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["<i>In vitro<\/i>\n                    activity of manogepix and comparators against infrequently encountered yeast and mold isolates from the SENTRY Surveillance Program (2017\u20132022)"],"prefix":"10.1128","volume":"68","author":[{"given":"Michael","family":"Pfaller","sequence":"first","affiliation":[{"name":"JMI Laboratories, North Liberty, lowa, USA"},{"name":"University of Iowa, Iowa City, lowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9769-9019","authenticated-orcid":false,"given":"Michael","family":"Huband","sequence":"additional","affiliation":[{"name":"JMI Laboratories, North Liberty, lowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Bien","sequence":"additional","affiliation":[{"name":"PAB Pharma Consulting LLC, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2734-3754","authenticated-orcid":false,"given":"Cecilia G.","family":"Carvalhaes","sequence":"additional","affiliation":[{"name":"JMI Laboratories, North Liberty, lowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby","family":"Klauer","sequence":"additional","affiliation":[{"name":"JMI Laboratories, North Liberty, lowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0126-1782","authenticated-orcid":false,"given":"Mariana","family":"Castanheira","sequence":"additional","affiliation":[{"name":"JMI Laboratories, North Liberty, lowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00214"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2374-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof5030067"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aambs.2019.10.003"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy358"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00211-19"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00203-6"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.10.4419-4431.2004"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02117-09"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01594-21"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9110922"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01747-08"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz568"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30784-2"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02032.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11124.1"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02081-21"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx066"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof8121285"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01784-20"},{"key":"e_1_3_3_23_2","volume-title":"Principles and procedures for the development of epidemiological cutoff values for antifungal susceptibility testing","author":"CLSI","year":"2016","unstructured":"CLSI. 2016. 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