{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T13:39:04Z","timestamp":1705844344852},"reference-count":15,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We evaluated the efficacy of posaconazole against\n            <jats:italic>Candida tropicalis<\/jats:italic>\n            in a systemic infection model with immunosuppressed mice. Posaconazole at 50 mg\/kg of body weight\/day prolonged the survival of mice and reduced the fungal tissue burden of mice infected with any of the five strains tested, with the exception of one strain that had a high MIC against this drug. Our results demonstrate the efficacy of posaconazole in the treatment of invasive murine infection caused by\n            <jats:italic>C. tropicalis<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.01136-09","type":"journal-article","created":{"date-parts":[[2009,10,20]],"date-time":"2009-10-20T01:29:39Z","timestamp":1256002179000},"page":"530-532","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of Posaconazole in a Murine Disseminated Infection by\n            <i>Can<\/i>\n            <i>dida tropicalis<\/i>"],"prefix":"10.1128","volume":"54","author":[{"given":"Marc\u0327al","family":"Marine\u0301","sequence":"first","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Cie\u0300ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. Javier","family":"Pastor","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Cie\u0300ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Guarro","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Cie\u0300ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.8.2477-2481.2002"},{"key":"e_1_3_2_3_2","unstructured":"Reference method for broth dilution antifungal susceptibility testing of yeasts. 2008"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.3884-3889.2005"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544020-00006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.4.1519-1527.2004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/IPC.0b013e318059b94b"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/323812"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01034-08"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070532"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/596757"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00409-07"},{"key":"e_1_3_2_13_2","first-page":"361","volume":"63","year":"2009","unstructured":"Rodr\u00edguez, M. M., F. J. Pastor, C. Serena, and J. Guarro. 2009. Posaconazole efficacy in a murine disseminated infection caused by Paecilomyces lilacinus. J. Antimicrob. Chemother.63:361-364.","journal-title":"J. Antimicrob. 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