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The Arg\n            <jats:sub>505<\/jats:sub>\n            Lys substitution did not impose an\n            <jats:italic>in vitro<\/jats:italic>\n            fitness cost, which may be one reason for its dominance among rifamycin-resistant clinical isolates. These observations were supported through the structural modeling of\n            <jats:italic>Cd<\/jats:italic>\n            RpoB. In general, most mutations lacked\n            <jats:italic>in vitro<\/jats:italic>\n            fitness costs, suggesting that rifamycin resistance may in some cases persist in the clinic.\n          <\/jats:p>","DOI":"10.1128\/aac.01137-16","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T02:58:59Z","timestamp":1467773939000},"page":"5604-5607","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden"],"prefix":"10.1128","volume":"60","author":[{"given":"Uyen T.","family":"Dang","sequence":"first","affiliation":[{"name":"Department of Biology, University of Texas at Arlington, Arlington, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idalia","family":"Zamora","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Texas at Arlington, Arlington, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk E.","family":"Hevener","sequence":"additional","affiliation":[{"name":"Biomedical and Pharmaceutical Sciences, College of Pharmacy, Idaho State University, Meridian, Idaho, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudip","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Texas at Arlington, Arlington, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&amp;M Health Science Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian G.","family":"Hurdle","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Texas at Arlington, Arlington, Texas, USA"},{"name":"Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&amp;M Health Science Center, Houston, Texas, USA"},{"name":"Department of Microbial and Molecular Pathogenesis, Texas A&amp;M Health Science Center, College of Medicine, Bryan, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/511870"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31814a4e97"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/596315"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00548-13"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00342-08"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.041087-0"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4366-4376.2004"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.298-309.2006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jam.12344"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1139\/cjm-2013-0903"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv231"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm4004889"},{"key":"e_1_3_3_14_2","volume-title":"version 2.0","author":"Schr\u00f6dinger","year":"2015","unstructured":"Schr\u00f6dinger. 2015. 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