{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:53:48Z","timestamp":1785430428053,"version":"3.56.0"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"The Construction Fund of Key Medical Disciplines of Hangzhou Laboratory Diagnostics","award":["2025HZZD01"],"award-info":[{"award-number":["2025HZZD01"]}]},{"name":"Zhejiang Provincial Medical and Health Technology Project","award":["2023KY168"],"award-info":[{"award-number":["2023KY168"]}]},{"name":"Zhejiang Provincial Medical and Health Technology Project","award":["2024KY229"],"award-info":[{"award-number":["2024KY229"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      This study identifies\n                      <jats:italic toggle=\"yes\">fosA12<\/jats:italic>\n                      , a novel chromosomally encoded fosfomycin resistance gene in a multidrug-resistant\n                      <jats:italic toggle=\"yes\">Proteus vulgaris<\/jats:italic>\n                      clinical isolate. Through whole-genome sequencing,\n                      <jats:italic toggle=\"yes\">fosA12<\/jats:italic>\n                      was characterized, showing 64.23% homology with\n                      <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                      \u2019s\n                      <jats:italic toggle=\"yes\">fosA<\/jats:italic>\n                      . FosA12, a glutathione S-transferase, confers high-level fosfomycin resistance (MIC 512 \u03bcg\/mL) via five critical residues. These findings highlight\n                      <jats:italic toggle=\"yes\">fosA12<\/jats:italic>\n                      \u2019s role in resistance and the need for clinical surveillance.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01138-25","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:51:36Z","timestamp":1776264696000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Identification and characteristics of a novel fosfomycin glutathione transferase, FosA12, from an MDR clinical isolate of\n                    <i>Proteus vulgaris<\/i>"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8953-9572","authenticated-orcid":true,"given":"Wei","family":"Lu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05pwsw714","id-type":"ROR","asserted-by":"publisher"}],"name":"Department 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