{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T09:16:27Z","timestamp":1649150187482},"reference-count":33,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The fungus\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Saprochaete capitata<\/jats:named-content>\n            causes opportunistic human infections, mainly in immunocompromised patients with hematological malignancies. The best therapy for this severe infection is still unknown. We evaluated the\n            <jats:italic>in vitro<\/jats:italic>\n            killing activity and the\n            <jats:italic>in vivo<\/jats:italic>\n            efficacy of posaconazole at 5, 10, or 20 mg\/kg twice a day (BID) in a murine neutropenic model of systemic infection with\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">S. capitata<\/jats:named-content>\n            by testing a set of six clinical isolates. Posaconazole showed fungistatic activity against all of the isolates tested. The different doses of the drug, especially the highest one, showed good efficacy, measured by prolonged survival, reduction of (1-3)-\u03b2-\n            <jats:sc>d<\/jats:sc>\n            -glucan levels in serum, tissue burden reduction, and histopathology.\n          <\/jats:p>","DOI":"10.1128\/aac.01140-15","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T02:23:49Z","timestamp":1442888629000},"page":"7477-7482","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of Posaconazole in a Murine Model of Systemic Infection by Saprochaete capitata"],"prefix":"10.1128","volume":"59","author":[{"given":"Pamela","family":"Thomson","sequence":"first","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Guarro","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Mayayo","sequence":"additional","affiliation":[{"name":"Unitat de Anatomia Patol\u00f2gica, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Capilla","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.3.753-755.1996"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2001.00699.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2005.01098.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2012.09.003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2012.12.003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-015-9869-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.535179"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1801.111192"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2013.02.004"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12303"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/380643"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3887"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12444"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-014-0668-3"},{"key":"e_1_3_2_16_2","first-page":"335","article-title":"In vitro activity of posaconazole against yeasts isolated in blood cultures","volume":"15","author":"Cant\u00f3n E","year":"2002","unstructured":"Cant\u00f3n E, Pem\u00e1n J, Orero A, Viudes A, Gil J, Rubio MC, Gobernado M. 2002. In vitro activity of posaconazole against yeasts isolated in blood cultures. Rev Esp Quimioter 15:335\u2013340. (In Spanish.)","journal-title":"Rev Esp Quimioter"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.12.3985-3988.2003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp138"},{"key":"e_1_3_2_19_2","first-page":"122","article-title":"Antifungal activity of posaconazole against Candida spp. and non-Candida clinical yeasts isolates","volume":"23","author":"Carrillo-Mu\u00f1oz J","year":"2010","unstructured":"Carrillo-Mu\u00f1oz J, Tur-Tur C, Hern\u00e1ndez-Molina J, Quind\u00f3s G, Marcos-Arias C, Eraso E, C\u00e1rdenes D, Ortiz-Maestro O, Santos P, Estivill D, Guardia C, Giusiano G. 2010. Antifungal activity of posaconazole against Candida spp. and non-Candida clinical yeasts isolates. 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