{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:35:34Z","timestamp":1773221734240,"version":"3.50.1"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Synergy time-kill studies against 40 methicillin-resistant\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            (MRSA) strains of differing resistance phenotypes were conducted. Subinhibitory concentrations of telavancin were combined with sub-MIC concentrations of other antimicrobial agents that might be used in combination with telavancin to provide Gram-negative coverage. The highest incidence of synergy was found after 24 h with gentamicin (90% of strains), followed by ceftriaxone (88%), rifampin and meropenem (each 65%), cefepime (45%), and ciprofloxacin (38%) for combinations tested at or below the intermediate breakpoint for each agent.\n          <\/jats:p>","DOI":"10.1128\/aac.01143-09","type":"journal-article","created":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T04:40:19Z","timestamp":1266381619000},"page":"2201-2205","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Antistaphylococcal Activities of Telavancin Tested Alone and in Combination by Time-Kill Assay"],"prefix":"10.1128","volume":"54","author":[{"given":"Gengrong","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, Pennsylvania 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn A.","family":"Pankuch","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, Pennsylvania 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois M.","family":"Ednie","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, Pennsylvania 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Appelbaum","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, Pennsylvania 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044194"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01351-09"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/595011"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.9.2295"},{"key":"e_1_3_2_6_2","unstructured":"Performance standards for antimicrobial susceptibility testing. 2009"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01455-06"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.2.428-438.2006"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.3.1079-1082.2006"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/498898"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki379"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/427701"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01641-07"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn124"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176667"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/427148"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki413"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/432475"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/425321"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.3.1127-1134.2005"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1086\/605332"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00559-07"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042859"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl235"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042683"},{"key":"e_1_3_2_26_2","unstructured":"Rubinstein E. G. R. Corey M. E. Stryjewski H. W. Boucher R. N. Daly F. C. Gentner S. L. Barriere M. M. Kitt and H. D. Friedland. 2008. Telavancin for hospital-acquired pneumonia including ventilator-associated pneumonia: the ATTAIN studies abstr. O75. Abstr. 18th Eur. Congr. Clin. Microbiol. Infect. Dis. Wiley-Blackwell Oxford United Kingdom."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/587896"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.3.862-867.2006"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1086\/429914"},{"key":"e_1_3_2_30_2","first-page":"3356","volume":"43","year":"2005","unstructured":"Takizawa, Y., I. Taneike, S. Nakagawa, T. Oishi, Y. Nitahara, N. Iwakura, K. Ozaki, M. Takano, T. Nakayama, and T. Yamamoto. 2005. A Panton-Valentine leukocidin (PVL)-positive community-acquired methicillin-resistant Staphylococcus aureus (MRSA) strain, another such strain carrying a multiple-drug resistance plasmid, and other more-typical PVL-negative MRSA strains found in Japan. Antimicrob. Agents Chemother.43:3356-3363.","journal-title":"Antimicrob. Agents Chemother."},{"key":"e_1_3_2_31_2","first-page":"108","volume":"44","year":"2006","unstructured":"Tenover, F. C., L. K. McDougal, R. V. Goering, G. Killgore, S. J. Projan, J. B. Patel, and P. M. Dunman. 2006. Characterization of a strain of community-associated methicillin-resistant Staphylococcus aureus widely disseminated in the United States. Antimicrob. Agents Chemother.44:108-118.","journal-title":"Antimicrob. 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