{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T07:32:41Z","timestamp":1768548761552,"version":"3.49.0"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) Task Order A13","doi-asserted-by":"publisher","award":["HHSN272201000038I"],"award-info":[{"award-number":["HHSN272201000038I"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006772","name":"a Voelcker Young Investigator Award from the Max and Minnie Tomerlin Voelcker Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida albicans<\/jats:named-content>\n            , normally found as a commensal in the gut, is a major human fungal pathogen responsible for both mucosal and systemic infections in a wide variety of immunocompromised individuals, including cancer patients and organ transplant recipients. The gastrointestinal tract represents a major portal of entry for the establishment of disseminated candidiasis in many of these individuals. Here we report the development of a diet-based mouse model for disseminated candidiasis acquired via the gastrointestinal tract. Using this model, as well as an appropriate immunosuppression regimen, we demonstrate that dissemination of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. albicans<\/jats:named-content>\n            from the gastrointestinal tract can result in mortality within 30 days postinfection. We also show a significant increase in fungal burden in systemic organs, but not gastrointestinal tract organs, upon immunosuppression. Importantly, we demonstrate that the administration of two widely used antifungals, fluconazole and caspofungin, either pre- or postimmunosuppression, significantly reduces fungal burdens. This model should prove to be of significant value for testing the ability of both established and experimental therapeutics to inhibit\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. albicans<\/jats:named-content>\n            dissemination from the gastrointestinal tract in an immunocompromised host as well as the subsequent mortality that can result from disseminated candidiasis.\n          <\/jats:p>","DOI":"10.1128\/aac.01144-16","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T02:03:38Z","timestamp":1472522618000},"page":"6703-6708","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Effect of Antifungal Treatment in a Diet-Based Murine Model of Disseminated Candidiasis Acquired via the Gastrointestinal Tract"],"prefix":"10.1128","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7237-8481","authenticated-orcid":false,"given":"David","family":"Kadosh","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura K.","family":"Najvar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"},{"name":"South Texas Veterans Health Care System, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosie","family":"Bocanegra","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"},{"name":"South Texas Veterans Health Care System, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Olivo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Kirkpatrick","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"},{"name":"South Texas Veterans Health Care System, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan P.","family":"Wiederhold","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"},{"name":"South Texas Veterans Health Care System, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.013"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/10454411990100030701"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-85-2-104"},{"key":"e_1_3_3_6_2","first-page":"341","volume-title":"Candida and candidiasis","author":"Filler SG","year":"2002","unstructured":"Filler SG, Kullberg BJ. 2002. Deep-seated candidal infections, p 341\u2013348. In Calderone R (ed), Candida and candidiasis. ASM Press, Washington, DC."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(98)01407-3"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/514731"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.2.361"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/319613"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)81257-1"},{"key":"e_1_3_3_12_2","volume-title":"Candida and candidosis","author":"Odds FC","year":"1988","unstructured":"Odds FC. 1988. Candida and candidosis, 2nd ed. Bailli\u00e8re Tindall, London, United Kingdom.","edition":"2"},{"key":"e_1_3_3_13_2","volume-title":"Candida and candidiasis","author":"Calderone RA","year":"2012","unstructured":"Calderone RA, Clancy CJ (ed). 2012. Candida and candidiasis, 2nd ed. ASM Press, Washington, DC.","edition":"2"},{"key":"e_1_3_3_14_2","first-page":"183","article-title":"Epidemiology of opportunistic invasive mycoses","volume":"7","author":"Kullberg BJ","year":"2002","unstructured":"Kullberg BJ, Oude Lashof AM. 2002. Epidemiology of opportunistic invasive mycoses. Eur J Med Res 7:183\u2013191.","journal-title":"Eur J Med Res"},{"key":"e_1_3_3_15_2","first-page":"S2","article-title":"Disseminated candidiasis in neutropenic patients","volume":"1","author":"Bodey GP","year":"1997","unstructured":"Bodey GP. 1997. Disseminated candidiasis in neutropenic patients. Int J Infect Dis 1(Suppl 1):S2\u2013S6.","journal-title":"Int J Infect Dis"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/68.1.29"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040035"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.25.2.702-707.1979"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3112"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e318045be83"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.5.950"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00196-13"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1313-1320.2005"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.58.4.1093-1100.1990"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47110-0"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2007.00287.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030184"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.07.005"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.8.1.192-195.2001"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.7.1558-1563.1987"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/00362178585380391"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(00)00165-6"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.1.109"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1139\/m81-068"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00328721"},{"key":"e_1_3_3_36_2","first-page":"1116","article-title":"Differences in virulence between two Candida albicans strains in experimental keratitis","volume":"41","author":"O'Day DM","year":"2000","unstructured":"O'Day DM, Head WS, Csank C, Shetlar DJ, Robinson RD, McCollum GW, Yang R, Zhu TL, Wang MX. 2000. Differences in virulence between two Candida albicans strains in experimental keratitis. Invest Ophthalmol Vis Sci 41:1116\u20131121.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064482"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.11.1939"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.01994.x"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-55"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012775390-4\/50154-8"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01144-16","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01144-16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:33:34Z","timestamp":1645475614000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01144-16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1128\/AAC.01144-16"],"URL":"https:\/\/doi.org\/10.1128\/aac.01144-16","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"2016-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}