{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:59:08Z","timestamp":1791273548239,"version":"4.1.0"},"reference-count":32,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Two novel isolates of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Candida glabrata<\/jats:named-content>\n            exhibiting reduced sensitivity to amphotericin B (MIC, 8 \u03bcg ml\n            <jats:sup>\u22121<\/jats:sup>\n            ) were found to be\n            <jats:italic>ERG2<\/jats:italic>\n            mutants, wherein \u0394\n            <jats:sup>8<\/jats:sup>\n            -sterol intermediates comprised &gt;90% of the total cellular sterol fraction. Both harbored an alteration at Thr\n            <jats:sup>121<\/jats:sup>\n            in ERG2; the corresponding residue (Thr\n            <jats:sup>119<\/jats:sup>\n            ) in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Saccharomyces cerevisiae<\/jats:named-content>\n            is essential for sterol \u03948-\u03947 isomerization. This constitutes the first report of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">C. glabrata<\/jats:named-content>\n            harboring mutations in\n            <jats:italic>ERG2<\/jats:italic>\n            and exhibiting reduced sensitivity to amphotericin B.\n          <\/jats:p>","DOI":"10.1128\/aac.01145-12","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T06:20:19Z","timestamp":1349158819000},"page":"6417-6421","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":89,"title":["Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations in\n            <i>ERG2<\/i>"],"prefix":"10.1128","volume":"56","author":[{"given":"Claire M.","family":"Hull","sequence":"first","affiliation":[{"name":"Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Bader","sequence":"additional","affiliation":[{"name":"University Medical Center G\u00f6ttingen, Institute for Medical Microbiology and German National Reference Center for Systemic Mycoses, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josie E.","family":"Parker","sequence":"additional","affiliation":[{"name":"Institute of Life Science, College of Medicine, Swansea University, Swansea, Wales, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weig","sequence":"additional","affiliation":[{"name":"University Medical Center G\u00f6ttingen, Institute for Medical Microbiology and German National Reference Center for Systemic Mycoses, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Gross","sequence":"additional","affiliation":[{"name":"University Medical Center G\u00f6ttingen, Institute for Medical Microbiology and German National Reference Center for Systemic Mycoses, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G. 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