{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:36:22Z","timestamp":1784259382649,"version":"3.55.0"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The ST5 lineage of methicillin-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>\n            (MRSA) is one of the most globally disseminated hospital-associated MRSA (HA-MRSA) lineages. We isolated a new local variant (designated ST764) over at least 5 years that causes invasive infections, including necrotizing fasciitis, and is carried by medical students, as well as household members. Analysis of the genome sequence of one isolate compared to that of the reference ST5 strain revealed that ST764 had acquired virulence traits similar to those of community-associated MRSA (CA-MRSA) through the acquisition of two new mobile genetic elements, ACMEII and SaPInn54, which carried ACME\n            <jats:italic>arcA<\/jats:italic>\n            and the staphylococcal enterotoxin B gene (\n            <jats:italic>seb<\/jats:italic>\n            ), respectively, and through enhanced expression of cytolytic peptide genes, although ST764 was negative for Panton-Valentine leukocidin. Other differences between ST764 and ST5 included the acquisition of an ACMEII-related cassette (cJR1), prophage \u03c62\n            <jats:sub>NN54<\/jats:sub>\n            , and streptococcal Tn\n            <jats:italic>5251<\/jats:italic>\n            and decreased numbers of copies of Tn\n            <jats:italic>554<\/jats:italic>\n            . As for superantigen genes, although the two possessed\n            <jats:italic>seg<\/jats:italic>\n            ,\n            <jats:italic>sei<\/jats:italic>\n            ,\n            <jats:italic>sem<\/jats:italic>\n            ,\n            <jats:italic>sen<\/jats:italic>\n            , and\n            <jats:italic>seo<\/jats:italic>\n            , ST764 lacked\n            <jats:italic>tst<\/jats:italic>\n            ,\n            <jats:italic>sec<\/jats:italic>\n            ,\n            <jats:italic>sel<\/jats:italic>\n            , and\n            <jats:italic>sep<\/jats:italic>\n            . The data suggest that ST764 MRSA is a novel hybrid variant of ST5 HA-MRSA with the characteristics of CA-MRSA and that the evolution of ST764 includes multiple steps, e.g., acquisition of novel or nonstaphylococcal mobile elements.\n          <\/jats:p>","DOI":"10.1128\/aac.01147-12","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T04:53:42Z","timestamp":1358225622000},"page":"1589-1595","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":64,"title":["A New Local Variant (ST764) of the Globally Disseminated ST5 Lineage of Hospital-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) Carrying the Virulence Determinants of Community-Associated MRSA"],"prefix":"10.1128","volume":"57","author":[{"given":"Tomomi","family":"Takano","sequence":"first","affiliation":[{"name":"Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata 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