{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:57:13Z","timestamp":1761929833232,"version":"3.41.2"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A novel 4-aminoquinoline derivative [(\n            <jats:italic>S<\/jats:italic>\n            )-7-chloro-\n            <jats:italic>N<\/jats:italic>\n            -(4-methyl-1-(4-methylpiperazin-1-yl)pentan-2-yl)-quinolin-4-amine triphosphate] exhibiting curative activity against chloroquine-resistant malaria parasites has been identified for preclinical development as a blood schizonticidal agent. The lead molecule selected after detailed structure-activity relationship (SAR) studies has good solid-state properties and promising activity against\n            <jats:italic>in vitro<\/jats:italic>\n            and\n            <jats:italic>in vivo<\/jats:italic>\n            experimental malaria models. The\n            <jats:italic>in vitro<\/jats:italic>\n            absorption, distribution, metabolism, and excretion (ADME) parameters indicate a favorable drug-like profile.\n          <\/jats:p>","DOI":"10.1128\/aac.01152-16","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T02:30:41Z","timestamp":1481596241000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Synthesis and Evaluation of Chirally Defined Side Chain Variants of 7-Chloro-4-Aminoquinoline To Overcome Drug Resistance in Malaria Chemotherapy"],"prefix":"10.1128","volume":"61","author":[{"given":"Vasantha Rao","family":"Dola","sequence":"first","affiliation":[{"name":"Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awakash","family":"Soni","sequence":"additional","affiliation":[{"name":"Division of Parasitology, Central Drug Research Institute, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooja","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Division of Parasitology, Central Drug Research Institute, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafsa","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics, Central Drug Research Institute, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanumuri Siva Rama","family":"Raju","sequence":"additional","affiliation":[{"name":"Division of Pharmacokinetics and Metabolism, Central Drug Research Institute, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamunur","family":"Rashid","sequence":"additional","affiliation":[{"name":"Division of Pharmacokinetics and Metabolism, Central Drug Research Institute, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Wahajuddin","sequence":"additional","affiliation":[{"name":"Division of Pharmacokinetics and Metabolism, Central Drug Research Institute, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumkum","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Division of Parasitology, Central Drug Research Institute, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Haq","sequence":"additional","affiliation":[{"name":"Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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