{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:01:49Z","timestamp":1785438109589,"version":"3.56.0"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Medicine and Health Plan Project of Zhejiang Province","award":["2024KY393"],"award-info":[{"award-number":["2024KY393"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070135"],"award-info":[{"award-number":["32070135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018553","name":"Wenzhou Science and Technology Plan Project","doi-asserted-by":"publisher","award":["Y20220030"],"award-info":[{"award-number":["Y20220030"]}],"id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,12,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Inducible macrolide resistance mediated by the\n                      <jats:italic toggle=\"yes\">erm<\/jats:italic>\n                      (41) T28 allele is a well-established intrinsic mechanism in\n                      <jats:italic toggle=\"yes\">Mycobacterium abscessus<\/jats:italic>\n                      . Here, we report a case of\n                      <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                      pulmonary disease in which an initial\n                      <jats:italic toggle=\"yes\">erm<\/jats:italic>\n                      (41) C28 isolate developed inducible resistance through a\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      C28T point mutation during prolonged therapy. To our knowledge, this case provides the first clinical evidence that\n                      <jats:italic toggle=\"yes\">erm<\/jats:italic>\n                      (41)-mediated inducible resistance can arise\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      under antimicrobial selective pressure.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01153-25","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T14:41:28Z","timestamp":1762440088000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Clinical emergence of inducible macrolide resistance mediated by acquired\n                    <i>erm<\/i>\n                    (41) C28T mutation in\n                    <i>Mycobacterium abscessus<\/i>"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6700-6920","authenticated-orcid":false,"given":"Guiqing","family":"He","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00w5h0n54","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Infectious Diseases, Wenzhou Central Hospital, The Dingli Clinical College of Wenzhou Medical University","place":["Wenzhou, China"]},{"id":[{"id":"https:\/\/ror.org\/00w5h0n54","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Infectious Diseases, Wenzhou Central Hospital, The Dingli Clinical College of Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shushu","family":"Zeng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/011ashp19","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathogen Biology, West China School of Basic Medical Sciences & 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