{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:52:09Z","timestamp":1790815929041,"version":"4.1.0"},"reference-count":35,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The in vitro and in vivo antifungal activities of T-2307, a novel arylamidine, were evaluated and compared with those of fluconazole, voriconazole, micafungin, and amphotericin B. T-2307 exhibited broad-spectrum activity against clinically significant pathogens, including\n            <jats:italic>Candida<\/jats:italic>\n            species (MIC range, 0.00025 to 0.0078 \u03bcg\/ml),\n            <jats:italic>Cryptococcus neoformans<\/jats:italic>\n            (MIC range, 0.0039 to 0.0625 \u03bcg\/ml), and\n            <jats:italic>Aspergillus<\/jats:italic>\n            species (MIC range, 0.0156 to 4 \u03bcg\/ml). Furthermore, T-2307 exhibited potent activity against fluconazole-resistant and fluconazole-susceptible-dose-dependent\n            <jats:italic>Candida albicans<\/jats:italic>\n            strains as well as against azole-susceptible strains. T-2307 exhibited fungicidal activity against some\n            <jats:italic>Candida<\/jats:italic>\n            and\n            <jats:italic>Aspergillus<\/jats:italic>\n            species and against\n            <jats:italic>Cryptococcus neoformans<\/jats:italic>\n            . In mouse models of disseminated candidiasis, cryptococcosis, and aspergillosis, the 50% effective doses of T-2307 were 0.00755, 0.117, and 0.391 mg\u00b7kg\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7dose\n            <jats:sup>\u22121<\/jats:sup>\n            , respectively. This agent was considerably more active than micafungin and amphotericin B against candidiasis and than amphotericin B against cryptococcosis, and its activity was comparable to the activities of micafungin and amphotericin B against aspergillosis. The results of preclinical in vitro and in vivo evaluations performed thus far indicate that T-2307 could represent a potent injectable agent for the treatment of candidiasis, cryptococcosis, and aspergillosis.\n          <\/jats:p>","DOI":"10.1128\/aac.01159-07","type":"journal-article","created":{"date-parts":[[2008,1,29]],"date-time":"2008-01-29T01:46:57Z","timestamp":1201571217000},"page":"1318-1324","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":108,"title":["In Vitro and In Vivo Antifungal Activities of T-2307, a Novel Arylamidine"],"prefix":"10.1128","volume":"52","author":[{"given":"Junichi","family":"Mitsuyama","sequence":"first","affiliation":[{"name":"Research Laboratories, Toyama Chemical Co. 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