{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:34:10Z","timestamp":1792798450331,"version":"4.5.0"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"MEC | Instituto de Salud Carlos III","award":["PI21\/00017, PI24\/00010, PMP22\/00092"],"award-info":[{"award-number":["PI21\/00017, PI24\/00010, PMP22\/00092"]}],"id":[{"id":"https:\/\/ror.org\/00ca2c886","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2024,11,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The mechanisms underlying ceftazidime\/avibactam resistance development in four ceftazidime\/avibactam susceptible\/resistant pairs of GES-5-producing ST235\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      clinical isolates were investigated. In three of the cases, ceftazidime\/avibactam resistance was driven by a single mutation leading to GES-27 (P162Q), GES-29 (P162A), or the novel GES-60 (N136S), as confirmed through cloning experiments. Moreover, these mutations were associated with increased cefiderocol MICs but reduced carbapenem, particularly imipenem\/relebactam, resistance. Understanding the complexity of resistance mechanisms to the growing repertoire of antipseudomonal \u03b2-lactams is crucial to guide optimized treatments and antimicrobial stewardship measures.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01164-24","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T09:03:46Z","timestamp":1729501426000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Mechanisms leading to\n                    <i>in vivo<\/i>\n                    ceftazidime\/avibactam resistance development during treatment of GES-5-producing\n                    <i>Pseudomonas aeruginosa<\/i>\n                    infections"],"prefix":"10.1128","volume":"68","author":[{"given":"Cristhian","family":"Herrera","sequence":"first","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario La Princesa, Madrid, 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