{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:56:14Z","timestamp":1787702174726,"version":"build-2784847793"},"reference-count":55,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,12,16]]},"abstract":"<jats:p>\n                    The impact of MexXY efflux pump expression on aminoglycoside resistance in clinical\n                    <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n                    isolates has been debated. In this study, we found that, in general, elevated\n                    <jats:italic>mexXY<\/jats:italic>\n                    gene expression levels in clinical\n                    <jats:named-content content-type=\"genus-species\">P. aeruginosa<\/jats:named-content>\n                    isolates confer to slight increases in aminoglycoside MIC levels; however, those levels rarely lead to clinically relevant resistance phenotypes. The main driver of resistance in the clinical isolates studied here was the acquisition of aminoglycoside-modifying enzymes (AMEs).\n                  <\/jats:p>","DOI":"10.1128\/aac.01166-20","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T09:14:35Z","timestamp":1602062075000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Expression of the MexXY Aminoglycoside Efflux Pump and Presence of an Aminoglycoside-Modifying Enzyme in Clinical Pseudomonas aeruginosa Isolates Are Highly Correlated"],"prefix":"10.1128","volume":"65","author":[{"given":"Alexander","family":"Seupt","sequence":"first","affiliation":[{"name":"Department of Molecular Bacteriology, Helmholtz Centre for Infection Research, Braunschweig, Germany"},{"name":"Department of Molecular Bacteriology, Twincore, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Schniederjans","sequence":"additional","affiliation":[{"name":"Department of Molecular Bacteriology, Helmholtz Centre for Infection Research, Braunschweig, Germany"},{"name":"Department of Molecular Bacteriology, Twincore, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3914-2781","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Tomasch","sequence":"additional","affiliation":[{"name":"Department of Molecular Bacteriology, Helmholtz Centre for Infection Research, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6141-9102","authenticated-orcid":false,"given":"Susanne","family":"H\u00e4ussler","sequence":"additional","affiliation":[{"name":"Department of Molecular Bacteriology, Helmholtz Centre for Infection Research, Braunschweig, Germany"},{"name":"Department of Molecular Bacteriology, Twincore, Hannover, Germany"},{"name":"Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark"},{"name":"Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1586\/eri.13.12"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-3-14"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00040-09"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.8815"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01681.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212527"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2907"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.10.125"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2016.1177460"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.16d30.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.08.004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2020.02.003"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1464"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2018.05.003"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450116666151001103948"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00421"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl504"},{"key":"e_1_3_3_19_2","first-page":"255","article-title":"Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms","volume":"3","author":"Poole K","year":"2001","unstructured":"Poole K. 2001. 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