{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T15:39:47Z","timestamp":1763480387969,"version":"3.41.2"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"MCTI | Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,11,17]]},"abstract":"<jats:p>\n            Phenotypic assay against\n            <jats:named-content content-type=\"genus-species\">Leishmania amazonensis<\/jats:named-content>\n            <jats:italic>in vitro<\/jats:italic>\n            and\n            <jats:italic>in vivo<\/jats:italic>\n            led to identification of an adamantyl-based phenyl sulfonyl acetamide (compound 1) as a promising antileishmanial agent. Compound 1 inhibited the growth of intracellular forms of\n            <jats:named-content content-type=\"genus-species\">L. amazonensis<\/jats:named-content>\n            (50% inhibitory concentration [IC\n            <jats:sub>50<\/jats:sub>\n            ] = 4\u2009\u03bcM) and exhibited low toxicity to host cells, with a selectivity index (SI) of &gt;125. However, in a cutaneous leishmaniasis (CL) mouse model, compound 1 did not reduce lesions and parasite load when administered as monotherapy or when given simultaneously with a suboptimal dose of miltefosine.\n          <\/jats:p>","DOI":"10.1128\/aac.01188-20","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T14:02:07Z","timestamp":1599746527000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["<i>In Vitro<\/i>\n            and\n            <i>In Vivo<\/i>\n            Evaluation of an Adamantyl-Based Phenyl Sulfonyl Acetamide against Cutaneous Leishmaniasis Models of\n            <i>Leishmania amazonensis<\/i>"],"prefix":"10.1128","volume":"64","author":[{"given":"Camila C.","family":"Santos","sequence":"first","affiliation":[{"name":"Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (IOC\/Fiocruz), Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaisheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Physics and Atmospheric Science, Jackson State University, Jackson, Mississippi, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos M.","family":"Batista","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (IOC\/Fiocruz), Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel M.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (IOC\/Fiocruz), Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly C.","family":"Demarque","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (IOC\/Fiocruz), Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia L.","family":"da Silva-Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology and Endemic Diseases, Oswaldo Cruz Institute (IOC\/Fiocruz), Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otac\u00edlio C.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology and Endemic Diseases, Oswaldo Cruz Institute (IOC\/Fiocruz), Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ifedayo Victor","family":"Ogungbe","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Physics and Atmospheric Science, Jackson State University, Jackson, Mississippi, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0078-6106","authenticated-orcid":false,"given":"Maria de Nazar\u00e9 C.","family":"Soeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular Biology (LBC), Oswaldo Cruz Institute (IOC\/Fiocruz), Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"e_1_3_3_3_2","volume-title":"Making medical history to meet the needs of neglected patients","author":"Drugs for Neglected Diseases initiative","year":"2018","unstructured":"Drugs for Neglected Diseases initiative. 2018. 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