{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:57:55Z","timestamp":1761238675062,"version":"3.41.2"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100019727","name":"Da Volterra","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100019727","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,12,20]]},"abstract":"<jats:p>\n            Fluoroquinolone treatments induce dysbiosis of the intestinal microbiota, resulting in loss of resistance to colonization by exogenous bacteria such as\n            <jats:named-content content-type=\"genus-species\">Clostridioides difficile<\/jats:named-content>\n            that may cause severe diarrhea in humans and lethal infection in hamsters. We show here that DAV131A, a charcoal-based adsorbent, decreases the intestinal levels of the fluoroquinolone antibiotics levofloxacin and ciprofloxacin in hamsters, protects their intestinal microbiota, and prevents lethal infection by\n            <jats:named-content content-type=\"genus-species\">C. difficile<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.01196-19","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T13:07:40Z","timestamp":1571404060000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["DAV131A Protects Hamsters from Lethal\n            <i>Clostridioides difficile<\/i>\n            Infection Induced by Fluoroquinolones"],"prefix":"10.1128","volume":"64","author":[{"given":"Nathalie","family":"Saint-Lu","sequence":"first","affiliation":[{"name":"Da Volterra, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Burdet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, IAME, INSERM, Paris, France"},{"name":"AP-HP, Bichat Hospital, Department of Epidemiology, Biostatistics, and Clinical Research, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Sablier-Gallis","sequence":"additional","affiliation":[{"name":"Da Volterra, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanguy","family":"Corbel","sequence":"additional","affiliation":[{"name":"Da Volterra, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agathe","family":"Nevi\u00e8re","sequence":"additional","affiliation":[{"name":"Da Volterra, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakina","family":"Sayah-Jeanne","sequence":"additional","affiliation":[{"name":"Da Volterra, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Pulse","sequence":"additional","affiliation":[{"name":"UNT Health Science Center, Fort Worth, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Weiss","sequence":"additional","affiliation":[{"name":"UNT Health Science Center, Fort Worth, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Ferreira","sequence":"additional","affiliation":[{"name":"GenoScreen, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Andremont","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, IAME, INSERM, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"France","family":"Mentr\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, IAME, INSERM, Paris, France"},{"name":"AP-HP, Bichat Hospital, Department of Epidemiology, Biostatistics, and Clinical Research, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8049-9283","authenticated-orcid":false,"given":"Jean","family":"de Gunzburg","sequence":"additional","affiliation":[{"name":"Da Volterra, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.15.40"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02176-12"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt129"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt477"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.03.008"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408913"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.359"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix604"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00543-17"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00925-18"},{"key":"e_1_3_3_12_2","first-page":"75","volume-title":"Antibiogram","author":"Kitzis MD","year":"2010","unstructured":"Kitzis MD. 2010. 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