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There is an urgent need to develop new drug targets and drug molecules to treat CE. Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a serine\/threonine protein kinase consisting of \u03b1, \u03b2, and \u03b3 subunits, plays a key role in the regulation of energy metabolism. However, the role of AMPK in regulating glucose metabolism in\n              <jats:italic>E. granulosus<\/jats:italic>\n              s.l. and its effects on parasite viability is unknown. In this study, we found that targeted knockdown of EgAMPK\u03b1 or a small-molecule AMPK inhibitor inhibited the viability of\n              <jats:italic>E. granulosus sensu stricto<\/jats:italic>\n              (s.s.) and disrupted the ultrastructure. The results of\n              <jats:italic>in vivo<\/jats:italic>\n              experiments showed that the AMPK inhibitor had a significant therapeutic effect on\n              <jats:italic>E. granulosus<\/jats:italic>\n              s.s.-infected mice and resulted in the loss of cellular structures of the germinal layer. In addition, the inhibition of the EgAMPK\/EgGLUT1 pathway limited glucose uptake and glucose metabolism functions in\n              <jats:italic>E. granulosus<\/jats:italic>\n              s.s.. Overall, our results suggest that EgAMPK can be a potential drug target for CE and that inhibition of EgAMPK activation is an effective strategy for the treatment of disease.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.01202-23","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T14:01:29Z","timestamp":1707832889000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Inhibition of AMPK activation in\n            <i>Echinococcus granulosus<\/i>\n            sensu stricto limits the parasite\u2019s glucose metabolism and survival"],"prefix":"10.1128","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0122-7433","authenticated-orcid":false,"given":"Mingzhi","family":"Yan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansen","family":"Su","sequence":"additional","affiliation":[{"name":"Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China"},{"name":"Anhui University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Bi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6210-4719","authenticated-orcid":false,"given":"Renyong","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China"},{"name":"Basic Medical College, Xinjiang Medical University, Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1770-574X","authenticated-orcid":false,"given":"Guodong","family":"L\u00fc","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China"},{"name":"College of Pharmacy, Xinjiang Medical University, Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00075-18"},{"key":"e_1_3_4_3_2","unstructured":"WHO. 2020. 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