{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:31:13Z","timestamp":1790289073377,"version":"4.1.0"},"reference-count":10,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,12,20]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Mycobacterium abscessus<\/jats:named-content>\n            is an extensively drug-resistant opportunistic pathogen that can cause chronic otomastoiditis. There are no evidence-based treatment regimens for this severe infection. We treated four children with\n            <jats:named-content content-type=\"genus-species\">M. abscessus<\/jats:named-content>\n            otomastoiditis with a structured regimen of topical imipenem and tigecycline, intravenous imipenem and tigecycline, and oral clofazimine and azithromycin and adjunctive surgery. This structured approach led to cure, with 1 year of follow-up after treatment.\n          <\/jats:p>","DOI":"10.1128\/aac.01203-19","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T11:22:41Z","timestamp":1570792961000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Successful Systemic and Topical Treatment of Mycobacterium abscessus Otomastoiditis"],"prefix":"10.1128","volume":"64","author":[{"given":"Floor","family":"van Wijk","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Amalia\u2019s Children Hospital, Radboud University Medical Center, Nijmegen, the Netherlands"},{"name":"University Hospital Brussels, Department of Pediatrics, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Waterval","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Radboud University Medical Center, Nijmegen, the Netherlands"},{"name":"Department of Otorhinolaryngology, Maastricht University Medical Center, Maastricht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"van Aerde","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Amalia\u2019s Children Hospital, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie S. V.","family":"Henriet","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Amalia\u2019s Children Hospital, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. J. Anton","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennaert C.","family":"Borra","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob E.","family":"Aarnoutse","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0581-2003","authenticated-orcid":false,"given":"Jakko","family":"van Ingen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","volume-title":"Susceptibility testing of mycobacteria, nocardiae, and other aerobic actinomycetes","author":"Clinical and Laboratory Standards Institute","year":"2011","unstructured":"Clinical and Laboratory Standards Institute. 2011. 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