{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:38:22Z","timestamp":1790069902513,"version":"4.0.1"},"reference-count":45,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/22488-3"],"award-info":[{"award-number":["2016\/22488-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>\n            The treatment and control of schistosomiasis, a neglected disease that affects more than 200 million people worldwide, rely on the use of a single drug, praziquantel. A vaccine has yet to be developed, and since new drug design and development is a lengthy and costly process, drug repurposing is a promising strategy. In this study, the efficacy of promethazine, a first-generation antihistamine, was evaluated against\n            <jats:named-content content-type=\"genus-species\">Schistosoma mansoni<\/jats:named-content>\n            <jats:italic>ex vivo<\/jats:italic>\n            and in a murine model of schistosomiasis.\n          <\/jats:p>","DOI":"10.1128\/aac.01208-19","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T14:15:28Z","timestamp":1568643328000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":45,"title":["Promethazine Exhibits Antiparasitic Properties\n            <i>In Vitro<\/i>\n            and Reduces Worm Burden, Egg Production, Hepatomegaly, and Splenomegaly in a Schistosomiasis Animal Model"],"prefix":"10.1128","volume":"63","author":[{"given":"Daniel B.","family":"Roquini","sequence":"first","affiliation":[{"name":"N\u00facleo de Pesquisa em Doen\u00e7as Negligenciadas, Universidade Guarulhos, Guarulhos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon M.","family":"Cogo","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Doen\u00e7as Negligenciadas, Universidade Guarulhos, Guarulhos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Mengarda","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Doen\u00e7as Negligenciadas, Universidade Guarulhos, Guarulhos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana F.","family":"Mazloum","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Doen\u00e7as Negligenciadas, Universidade Guarulhos, Guarulhos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane S.","family":"Morais","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Doen\u00e7as Negligenciadas, Universidade Guarulhos, Guarulhos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rog\u00e9rio P.","family":"Xavier","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Doen\u00e7as Negligenciadas, Universidade Guarulhos, Guarulhos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Salvadori","sequence":"additional","affiliation":[{"name":"Instituto de F\u00edsica, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda S.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Instituto de F\u00edsica, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz E.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o e Imunologia, Universidade Guarulhos, Guarulhos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro L.","family":"Pinto","sequence":"additional","affiliation":[{"name":"N\u00facleo de Enteroparasitas, Instituto Adolfo Lutz, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago R.","family":"Morais","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Doen\u00e7as Negligenciadas, Universidade Guarulhos, Guarulhos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josu\u00e9","family":"de Moraes","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Doen\u00e7as Negligenciadas, Universidade Guarulhos, Guarulhos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0013-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2017-0112"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02582-16"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.08.002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01371-15"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.11.005"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13895"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010286"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14081"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.04.029"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01722-18"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/151509"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra033121"},{"key":"e_1_3_2_15_2","first-page":"337","article-title":"H1-antihistamines and the central nervous system","volume":"17","author":"Welch MJ","year":"2002","unstructured":"Welch MJ, Meltzer EO, Simons F. 2002. H1-antihistamines and the central nervous system. Clin Allergy Immunol 17:337\u2013388.","journal-title":"Clin Allergy Immunol"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182005008565"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2015.07.003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.04.006"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2015.09.001"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2144"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986713804806694"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.12.057"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed3040125"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.06.005"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1737"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2006.01.007"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33221"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001474"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19033793"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.04.032"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2003.12.009"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001455"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004181"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9574LSF"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcn153"},{"key":"e_1_3_2_36_2","first-page":"43936","volume-title":"Current topics in tropical medicine","author":"de Moraes J","year":"2012","unstructured":"de Moraes J. 2012. Antischistosomal natural compounds: present challenges for new drug screens, p 43936. Current topics in tropical medicine. IntechOpen. https:\/\/www.intechopen.com\/books\/current-topics-in-tropical-medicine\/antischistosomal-natural-compounds-present-challenges-for-new-drug-screens."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2015.06.009"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003656"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196667"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0101-y"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2004.71.206"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002617"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2017-0308"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.12.003"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2018.02.012"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14153"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01208-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01208-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:28:07Z","timestamp":1645478887000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01208-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1128\/AAC.01208-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.01208-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"2019-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01208-19"}}