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Given the profound deleterious inflammatory effects of the major \u03b2-glucan cell wall carbohydrate constituents of\n            <jats:italic>Pneumocystis<\/jats:italic>\n            through Dectin-1 engagement and downstream caspase recruitment domain-containing protein 9 (CARD9) immune activation, we sought to determine whether the pharmacodynamic activity of the known CARD9 inhibitor BRD5529 might have a therapeutic effect on macrophage innate immune signaling and subsequent downstream anti-inflammatory activity.\n          <\/jats:p>","DOI":"10.1128\/aac.01210-20","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T13:00:51Z","timestamp":1597928451000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Targeting CARD9 with Small-Molecule Therapeutics Inhibits Innate Immune Signaling and Inflammatory Response to Pneumocystis carinii 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