{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:26:18Z","timestamp":1789680378846,"version":"4.0.1"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We tested the activity of ETX0914 against 187\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Neisseria gonorrhoeae<\/jats:named-content>\n            isolates from men with urethritis in Nanjing, China, in 2013. The MIC\n            <jats:sub>50<\/jats:sub>\n            , MIC\n            <jats:sub>90<\/jats:sub>\n            , and MIC range for ETX0914 were 0.03 \u03bcg\/ml, 0.06 \u03bcg\/ml, and \u22640.002 to 0.125 \u03bcg\/ml, respectively. All isolates were resistant to ciprofloxacin, and 36.9% (69\/187) were resistant to azithromycin. Of the isolates, 46.5% were penicillinase-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">N. gonorrhoeae<\/jats:named-content>\n            (PPNG), 36% were tetracycline-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">N. gonorrhoeae<\/jats:named-content>\n            (TRNG), and 13% (24 isolates) had an MIC of 0.125 \u03bcg\/ml for ceftriaxone. ETX0914 may be an effective treatment option for gonorrhea.\n          <\/jats:p>","DOI":"10.1128\/aac.01211-15","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T12:34:21Z","timestamp":1445344461000},"page":"621-623","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914)"],"prefix":"10.1128","volume":"60","author":[{"given":"Xiao-Hong","family":"Su","sequence":"first","affiliation":[{"name":"National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Xi","family":"Wang","sequence":"additional","affiliation":[{"name":"National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jing","family":"Le","sequence":"additional","affiliation":[{"name":"National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Rong","family":"Liu","sequence":"additional","affiliation":[{"name":"National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Wan","sequence":"additional","affiliation":[{"name":"National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Li","sequence":"additional","affiliation":[{"name":"National Center for STD and Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Alm","sequence":"additional","affiliation":[{"name":"Macrolide Pharmaceuticals, Lexington, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Entasis Therapeutics, Waltham, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Rice","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Unemo M Golparian D Syversen G Vestrheim DF Moi H. 2010. Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment Norway 2010. Euro Surveill 15:pii=19721. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=19721.","DOI":"10.2807\/ese.15.47.19721-en"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Ison CA Hussey J Sankar KN Evans J Alexander S. 2011. Gonorrhoea treatment failures to cefixime and azithromycin in England 2010. Euro Surveill 16:pii=19833. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=19933.","DOI":"10.2807\/ese.16.14.19833-en"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Unemo M Golparian D Stary A Eigentler A. 2011. First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria 2011. 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Treatment failure of pharyngeal gonorrhoea with internationally recommended first-line ceftriaxone verified in Slovenia September 2011. Euro Surveill 17:20200. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=20200.","DOI":"10.2807\/ese.17.25.20200-en"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"Golparian D Ohlsson A Janson H Lidbrink P Richtner T Ekelund O Fredlund H Unemo M. 2014. Four treatment failures of pharyngeal gonorrhoea with ceftriaxone (500 mg) or cefotaxime (500 mg) Sweden 2013 and 2014. 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