{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:11:48Z","timestamp":1792257108921,"version":"4.4.0"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100020024","name":"KfW Entwicklungsbank","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006456","name":"Bundesministerium f\u00fcr Wirtschaftliche Zusammenarbeit und Entwicklung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006456","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00fcr Infektionsforschung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Helminthiasis remains a public health issue in endemic areas. Various drugs have been proposed to improve efficacy against helminths. The study aimed to assess the safety and efficacy of three different anthelmintic combinations to treat\n              <jats:italic>Trichuris trichiura<\/jats:italic>\n              infections. We conducted a randomized assessors-blind clinical trial involving children aged 2\u201317 years with\n              <jats:italic>T. trichiura<\/jats:italic>\n              . Participants were randomly assigned to one of three treatment arms. On the first and third days, all participants got albendazole 400 mg, and on the second day, albendazole (arm A), mebendazole 500 mg (arm B), or pyrantel 125 mg\/kg (arm C). We assessed treatment efficacy using the cure rate (CR) and egg reduction rate (ERR) at 3 and 6 weeks post-treatment. At 3 weeks post-treatment, ERR and CR were highest in study arm A [ERR = 94%, 95% confidence interval (CI): 92\u201395; CR = 71%; 95% CI: 58\u201381] compared to the B and C arms. Decrease in ERR was significant only for arm B versus arm A (\n              <jats:italic>P<\/jats:italic>\n              -value &lt;0.001); decrease in ERR was significant for arms B and C (\n              <jats:italic>P<\/jats:italic>\n              -value &lt;0.001). No statistical difference was observed in CR when comparing arms A and B (\n              <jats:italic>P<\/jats:italic>\n              -value =1.00) and C (\n              <jats:italic>P<\/jats:italic>\n              -value =0.27). At 6 weeks, a decrease in ERR was observed in three arms, significant only for arm C, 81% (95% CI: 78\u201383). A significant increase in egg counts was observed between 3 and 6 weeks post-treatment. All treatments were safe with mild adverse events. Albendazole 400 mg\/day (arm A) showed the highest efficacy against trichuriasis. Nonetheless, this treatment regimen was able to cure half of the treated individuals highlighting concerns about controlling the transmission of\n              <jats:italic>T. trichiura<\/jats:italic>\n              .\n            <\/jats:p>\n            <jats:sec>\n              <jats:title>CLINICAL TRIAL<\/jats:title>\n              <jats:p>\n                Registered at ClinicalTrials.gov (\n                <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT04326868\" xlink:type=\"simple\">NCT04326868<\/jats:ext-link>\n                ).\n              <\/jats:p>\n            <\/jats:sec>\n          <\/jats:sec>","DOI":"10.1128\/aac.01211-23","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T14:15:39Z","timestamp":1712067339000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["A randomized assessors-blind clinical trial to evaluate the safety and the efficacy of albendazole alone and in combination with mebendazole or pyrantel for the treatment of\n            <i>Trichuris trichiura<\/i>\n            infection in school-aged children in Lambar\u00e9n\u00e9 and surroundings"],"prefix":"10.1128","volume":"68","author":[{"given":"Paul Alvyn","family":"Nguema Moure","sequence":"first","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"},{"name":"Ecole Doctorale R\u00e9gionale d\u2019Afrique Centrale en Infectiologie Tropicale de Franceville, Franceville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustapha","family":"Nzamba Maloum","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9d\u00e9on Prince","family":"Manouana","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"},{"name":"Institute of Tropical Medicine, Universit\u00e4tsklinikum T\u00fcbingen, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rom\u00e9o-Aim\u00e9","family":"Laclong Lontchi","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirabeau","family":"Mbong Ngwese","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Ronald","family":"Edoa","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannot","family":"Fr\u00e9jus Zinsou","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"},{"name":"Institute of Tropical Medicine, Universit\u00e4tsklinikum T\u00fcbingen, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Meulah","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"},{"name":"Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saidou","family":"Mahmoudou","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsy Mirna","family":"N'noh Dansou","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabo","family":"Josiane Honkpehedji","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"},{"name":"Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayode","family":"Romeo Adegbite","sequence":"additional","affiliation":[{"name":"Centre de Recherches M\u00e9dicales de Lambar\u00e9n\u00e9, Lambar\u00e9n\u00e9, Gabon"},{"name":"Institute of Tropical Medicine, Universit\u00e4tsklinikum T\u00fcbingen, Universit\u00e4t T\u00fcbingen, T\u00fcbingen, 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