{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:57:33Z","timestamp":1770508653062,"version":"3.49.0"},"reference-count":16,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Isavuconazole is the active component of the new azole antifungal agent BAL8557, which is entering phase III clinical development. This study was conducted to compare the in vitro activities of isavuconazole and five other antifungal agents against 296\n            <jats:italic>Candida<\/jats:italic>\n            isolates that were recovered consecutively from blood cultures between 1995 and 2004 at a tertiary care university hospital. Microdilution testing was done in accordance with CLSI (formerly NCCLS) guideline M27-A2 in RPMI-1640 MOPS (morpholinepropanesulfonic acid) broth. The antifungal agents tested were amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole, and isavuconazole.\n            <jats:italic>C. albicans<\/jats:italic>\n            was the most common species, representing 57.1% of all isolates. There was no trend found in favor of non-\n            <jats:italic>Candida albicans<\/jats:italic>\n            species over time. In terms of MIC\n            <jats:sub>50<\/jats:sub>\n            s, isavuconazole was more active (0.004 mg\/liter) than amphotericin B (0.5 mg\/liter), itraconazole (0.008 mg\/liter), voriconazole (0.03 mg\/liter), flucytosine (0.125 mg\/liter), and fluconazole (8 mg\/liter). For isavuconazole, MIC\n            <jats:sub>50<\/jats:sub>\n            s\/MIC\n            <jats:sub>90<\/jats:sub>\n            s ranged from 000.2\/0.004 mg\/liter for\n            <jats:italic>C. albicans<\/jats:italic>\n            to 0.25\/0.5 mg\/liter for\n            <jats:italic>C. glabrata<\/jats:italic>\n            . Two percent of isolates (\n            <jats:italic>C. glabrata<\/jats:italic>\n            and\n            <jats:italic>C. krusei<\/jats:italic>\n            ) were resistant to fluconazole;\n            <jats:italic>C. albicans<\/jats:italic>\n            strains resistant to fluconazole were not detected. There were only two isolates with MICs for isavuconazole that were &gt;0.5 mg\/liter: both were\n            <jats:italic>C. glabrata<\/jats:italic>\n            isolates, and the MICs were 2 and 4 mg\/liter, respectively. In conclusion, isavuconazole is highly active against\n            <jats:italic>Candida<\/jats:italic>\n            bloodstream isolates, including fluconazole-resistant strains. It was more active than itraconazole and voriconazole against\n            <jats:italic>C. albicans<\/jats:italic>\n            and\n            <jats:italic>C. glabrata<\/jats:italic>\n            and appears to be a promising agent against systemic\n            <jats:italic>Candida<\/jats:italic>\n            infections.\n          <\/jats:p>","DOI":"10.1128\/aac.01217-06","type":"journal-article","created":{"date-parts":[[2007,2,17]],"date-time":"2007-02-17T01:59:10Z","timestamp":1171677550000},"page":"1818-1821","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":73,"title":["In Vitro Activities of Isavuconazole and Other Antifungal Agents against\n            <i>Candida<\/i>\n            Bloodstream Isolates"],"prefix":"10.1128","volume":"51","author":[{"given":"H.","family":"Seifert","sequence":"first","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Aurbach","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Stefanik","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Cornely","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67490-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf074"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022139"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021585"},{"key":"e_1_3_2_6_2","unstructured":"NCCLS document M27-A2. 2002"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.10.3149-3154.2003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.3.852-856.2002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.12.3242"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.2.235"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00163-06"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.279-285.2006"},{"key":"e_1_3_2_13_2","unstructured":"Abstr. 44th Intersci. Conf. Antimicrob. Agents Chemother. 2004"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki399"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl396"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/421946"},{"key":"e_1_3_2_17_2","unstructured":"Abstr. 42nd Intersci. Conf. Antimicrob. Agents Chemother. 2002"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01217-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01217-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:18:34Z","timestamp":1645471114000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01217-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1128\/AAC.01217-06"],"URL":"https:\/\/doi.org\/10.1128\/aac.01217-06","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"2006-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-02-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}