{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:51:23Z","timestamp":1790077883435,"version":"4.0.1"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We compared the kinetics of amphotericin B (AMB) lung accumulation and fungal clearance by liposomal amphotericin B (L-AMB) and amphotericin B lipid complex (ABLC) in a neutropenic murine model of invasive pulmonary mucormycosis (IPM). Immunosuppressed BALB\/c mice were inoculated with 1 \u00d7 10\n            <jats:sup>6<\/jats:sup>\n            <jats:italic>Rhizopus oryzae<\/jats:italic>\n            spores and administered L-AMB or ABLC at daily intravenous doses of 1, 5, or 10 mg\/kg of body weight for 5 days starting 12 h after infection. At a dose of 10 mg\/kg\/day, both L-AMB and ABLC were effective at reducing the\n            <jats:italic>R. oryzae<\/jats:italic>\n            lung fungal burden and achieved lung tissue concentrations exceeding the isolate mean fungicidal concentration (MFC) of 8 \u03bcg\/ml by 72 h. When ABLC was dosed at 5 mg\/kg\/day, the ABLC-treated animals had significantly higher AMB lung concentrations than the L-AMB treated animals at 24 h (6.64 and 1.44 \u03bcg\/g, respectively;\n            <jats:italic>P =<\/jats:italic>\n            0.013) and 72 h (7.49 and 1.03 \u03bcg\/g, respectively;\n            <jats:italic>P<\/jats:italic>\n            = 0.005), and these higher concentrations were associated with improved fungal clearance, as determined by quantitative real-time PCR (mean conidial equivalent of\n            <jats:italic>R. oryzae<\/jats:italic>\n            DNA per lung, 4.44 \u00b1 0.44 and 6.57 \u00b1 0.74 log\n            <jats:sub>10<\/jats:sub>\n            , respectively;\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). Analysis of the AMB tissue concentration-response relationships revealed that the suppression of\n            <jats:italic>R. oryzae<\/jats:italic>\n            growth in the lung required tissue concentrations that approached the MFC for the infecting isolate (50% effective concentration, 8.19 \u03bcg\/g [95% confidence interval, 2.81 to 18.1 \u03bcg\/g]). The rates of survival were similar in the animals treated with L-AMB and ABLC at 10 mg\/kg\/day. These data suggest that higher initial doses may be required during L-AMB treatment than during ABLC treatment of experimental IPM.\n          <\/jats:p>","DOI":"10.1128\/aac.01222-09","type":"journal-article","created":{"date-parts":[[2009,12,29]],"date-time":"2009-12-29T01:54:15Z","timestamp":1262051655000},"page":"1298-1304","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":74,"title":["Comparative Pharmacodynamics of Amphotericin B Lipid Complex and Liposomal Amphotericin B in a Murine Model of Pulmonary Mucormycosis"],"prefix":"10.1128","volume":"54","author":[{"given":"Russell E.","family":"Lewis","sequence":"first","affiliation":[{"name":"University of Houston College of Pharmacy"},{"name":"The University of Texas M. D. Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan D.","family":"Albert","sequence":"additional","affiliation":[{"name":"The University of Texas M. D. Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangling","family":"Liao","sequence":"additional","affiliation":[{"name":"University of Houston College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingguo","family":"Hou","sequence":"additional","affiliation":[{"name":"University of Houston College of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall A.","family":"Prince","sequence":"additional","affiliation":[{"name":"University of Houston College of Pharmacy"},{"name":"The University of Texas M. D. Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios P.","family":"Kontoyiannis","sequence":"additional","affiliation":[{"name":"University of Houston College of Pharmacy"},{"name":"The University of Texas M. D. Anderson Cancer Center, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.1.164"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.1.494-503.2005"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.834-840.2002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1998.tb04464.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/590004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/514341"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.10.3776-3781.2002"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00241-06"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.721-727.2005"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01488-07"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2006.06.003"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/428780"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/597615"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/521245"},{"key":"e_1_3_2_17_2","unstructured":"Antimicrob. 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