{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T15:43:58Z","timestamp":1776008638115,"version":"3.50.1"},"reference-count":77,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R21AI146540"],"award-info":[{"award-number":["R21AI146540"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI153545"],"award-info":[{"award-number":["R21AI153545"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["5T32GM081061"],"award-info":[{"award-number":["5T32GM081061"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2023,2,16]]},"abstract":"<jats:p>Macrocyclic lactones are front-line therapies for parasitic roundworm infections; however, there are no comprehensive studies on the activity of this drug class against parasitic flatworms. Ivermectin is well known to be inactive against flatworms.<\/jats:p>","DOI":"10.1128\/aac.01230-22","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T09:01:36Z","timestamp":1674637296000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Phenotypic Profiling of Macrocyclic Lactones on Parasitic\n                    <i>Schistosoma<\/i>\n                    Flatworms"],"prefix":"10.1128","volume":"67","author":[{"given":"Kaetlyn T.","family":"Ryan","sequence":"first","affiliation":[{"name":"Department of Pathobiological Sciences, University of Wisconsin - Madison, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas J.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, University of Wisconsin - Madison, Madison, Wisconsin, USA"},{"name":"Department of Biology, University of Wisconsin - Eau Claire, Eau Claire, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac K.","family":"Kamara","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Wisconsin - Oshkosh, Oshkosh, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailey","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Wisconsin - Oshkosh, Oshkosh, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith E.","family":"Humphries","sequence":"additional","affiliation":[{"name":"Department of Biology, Lawrence University, Appleton, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-1760","authenticated-orcid":true,"given":"Mostafa","family":"Zamanian","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, University of Wisconsin - Madison, Madison, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4986-972X","authenticated-orcid":true,"given":"John D.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, University of Wisconsin - Madison, Madison, Wisconsin, USA"},{"name":"Department of Chemistry, University of Wisconsin - Oshkosh, Oshkosh, Wisconsin, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2020.07.001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1996.55.214"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1471-4922(01)02209-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.18-0752"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.51.83"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abj9114"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01402-5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20092-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb7709"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007743"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003593"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2020.10.005"},{"key":"e_1_3_3_14_2","first-page":"749","article-title":"Effect of avermectin B1a on chick neuronal gamma-aminobutyrate receptor channels expressed in Xenopus oocytes","volume":"32","author":"Sigel E","year":"1987","unstructured":"Sigel E, Baur R. 1987. Effect of avermectin B1a on chick neuronal gamma-aminobutyrate receptor channels expressed in Xenopus oocytes. Mol Pharmacol 32:749\u2013752.","journal-title":"Mol Pharmacol"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.53.2.283"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-17-07289.1999"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011264200"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6308762"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.45.100191.002305"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(95)00026-x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84009-y"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003586"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2017.31"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000464"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/167265"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201800237"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(94)00743-v"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005008"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003962"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00754"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2.S1.S53"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001494"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000723"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010937"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03809-14"},{"key":"e_1_3_3_36_2","first-page":"147","volume-title":"Current chemotherapy","author":"Stohler HR","year":"1978","unstructured":"Stohler HR. 1978. Ro 11\u20133128, a novel schistosomicidal compound. Current chemotherapy 1:147\u2013148."},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1966.tb01845.x"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1983.32.83"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35755"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.33.5.475"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.2307\/3281177"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2021.105010"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007826"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00925943"},{"key":"e_1_3_3_45_2","first-page":"617","article-title":"Preliminary results in human schistosomiasis with Ro 11\u20133128","volume":"55","author":"Baard AP","year":"1979","unstructured":"Baard AP, Sommers DK, Honiball PJ, Fourie ED, Du Toit LE. 1979. Preliminary results in human schistosomiasis with Ro 11\u20133128. S Afr Med J 55:617\u2013618.","journal-title":"S Afr Med J"},{"key":"e_1_3_3_46_2","unstructured":"Merck Research Laboratories. 1996. FDA approval package application # 050742."},{"key":"e_1_3_3_47_2","unstructured":"Committee for Veterinary Medicinal Products. 1999. European Agency for the Evaluation of Medicinal Products Summary Report on Emamectin."},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1109\/icbbe.2010.5516689"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1984"},{"key":"e_1_3_3_50_2","doi-asserted-by":"crossref","unstructured":"McDermott-Rouse A Minga E Barlow I Feriani L. 2021. Behavioral fingerprints predict insecticide and anthelmintic mode of action. bioRxiv.","DOI":"10.1101\/2021.01.27.428391"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2021.05.004"},{"key":"e_1_3_3_52_2","doi-asserted-by":"crossref","unstructured":"Wheeler NJ Ryan KT Gallo KJ Henthorn CR Ericksen SS Chan JD Zamanian M. 2022. Multivariate chemogenomic screening prioritizes new macrofilaricidal leads. bioRxiv.","DOI":"10.1101\/2022.07.25.501423"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03206-1"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-019-3747-6"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14476"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2001)087[0692:COIDSA]2.0.CO;2"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.6.2674"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011983107"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006438"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12036"},{"key":"e_1_3_3_61_2","doi-asserted-by":"crossref","unstructured":"Henthorn CR Airs PM Neumann E Zamanian M. 2022. Resolving the origins of secretory products and anthelmintic responses in a human parasitic nematode at single-cell resolution. bioRxiv.","DOI":"10.1101\/2022.08.30.505865"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2017.02.004"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP275236"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.07.010"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2012.05.002"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.064295"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107635200"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004181"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2003.12.009"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151934"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2006.11.009"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12029"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2015.01.018"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2016.04.007"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009920"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.03.097"},{"key":"e_1_3_3_77_2","doi-asserted-by":"crossref","unstructured":"Noonan JD Beech RN. 2022. Reconstitution of an N-AChR from Brugia malayi. bioRxiv.","DOI":"10.1101\/2022.06.01.493574"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.3791\/56345"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01230-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01230-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T09:03:02Z","timestamp":1676538182000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.01230-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":77,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2,16]]}},"alternative-id":["10.1128\/aac.01230-22"],"URL":"https:\/\/doi.org\/10.1128\/aac.01230-22","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.09.12.507717","asserted-by":"object"}]},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,16]]},"assertion":[{"value":"2022-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01230-22"}}