{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:21:42Z","timestamp":1790727702628,"version":"4.1.0"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100014055","name":"DOD | United States Army | MEDCOM | MRMC | U.S. Army Medical Research Acquisition Activity","doi-asserted-by":"publisher","award":["W81XWH-16-1-0245"],"award-info":[{"award-number":["W81XWH-16-1-0245"]}],"id":[{"id":"10.13039\/100014055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>\n                    Bacteriophage-derived lysins are being developed as anti-infective agents. In an acute osteomyelitis methicillin-resistant\n                    <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n                    (MRSA) model, rats receiving no treatment or treatment with daptomycin, exebacase (CF-301), or daptomycin plus exebacase had means of 5.13, 4.09, 4.65, and 3.57 log\n                    <jats:sub>10<\/jats:sub>\n                    CFU\/gram of bone, respectively.\n                  <\/jats:p>","DOI":"10.1128\/aac.01235-19","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T08:53:45Z","timestamp":1564476825000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Exebacase in Addition to Daptomycin Is More Active than Daptomycin or Exebacase Alone in Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats"],"prefix":"10.1128","volume":"63","author":[{"given":"Melissa J.","family":"Karau","sequence":"first","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzannah M.","family":"Schmidt-Malan","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Xiangya Hospital of Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerryl E.","family":"Greenwood-Quaintance","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayawant","family":"Mandrekar","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Lehoux","sequence":"additional","affiliation":[{"name":"ContraFect, Yonkers, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4324-573X","authenticated-orcid":false,"given":"Raymond","family":"Schuch","sequence":"additional","affiliation":[{"name":"ContraFect, Yonkers, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Cassino","sequence":"additional","affiliation":[{"name":"ContraFect, Yonkers, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6344-4141","authenticated-orcid":false,"given":"Robin","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA"},{"name":"Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2016.10.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00084-17"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq146"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214161"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0000000000001152"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit637"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173919"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02666-16"},{"key":"e_1_3_2_10_2","unstructured":"ClinicalTrials.gov. 2017. Safety efficacy and pharmacokinetics of CF-301 vs. placebo in addition to antibacterial therapy for treatment of S. aureus bacteremia NCT 03163446. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03163446. Accessed 18 March 2019."},{"key":"e_1_3_2_11_2","volume-title":"29th European Congress of Clinical Microbiology and Infectious Diseases Annual Meeting","author":"Fowler VG","year":"2019","unstructured":"Fowler VG, Das A, Lipka J, Schuch R, Cassino C. 2019. Exebacase (lysin CF-301) improved clinical responder rates in methicillin-resistant Staphylococcus aureus bacteremia and endocarditis compared to standard of care antibiotics alone in a first-in-patient phase 2 study. 29th European Congress of Clinical Microbiology and Infectious Diseases Annual Meeting, 13 to 16 April, 2019, Amsterdam, the Netherlands."},{"key":"e_1_3_2_14_2","unstructured":"Reference deleted."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2016.01.008"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/B978-012775390-4\/50205-0","volume-title":"Handbook of animal models of infection","author":"O\u2019Reilly T","year":"1999","unstructured":"O\u2019Reilly T, Mader J. 1999. Rat model of bacterial osteomyelitis of the tibia, p 561\u2013575. In Zak O, Sande M (ed), Handbook of animal models of infection. Academic Press, San Diego, CA."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki435"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01609-15"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/2193-1801-2-329"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02344-14"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01235-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01235-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:33:21Z","timestamp":1645461201000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01235-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1128\/AAC.01235-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.01235-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"2019-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01235-19"}}