{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:21:13Z","timestamp":1791235273208,"version":"4.1.0"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            To compare the\n            <jats:italic>in vitro<\/jats:italic>\n            antibacterial efficacies and resistance profiles of rifampin-based combinations against methicillin-resistant\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Staphylococcus aureus<\/jats:named-content>\n            (MRSA) in a biofilm model, the antibacterial activities of vancomycin, teicoplanin, daptomycin, minocycline, linezolid, fusidic acid, fosfomycin, and tigecycline alone or in combination with rifampin against biofilm-embedded MRSA were measured. The rifampin-resistant mutation frequencies were evaluated. Of the rifampin-based combinations, rifampin enhances the antibacterial activities of and even synergizes with fusidic acid, tigecycline, and, to a lesser extent, linezolid, fosfomycin, and minocycline against biofilm-embedded MRSA. Such combinations with weaker rifampin resistance induction activities may provide a therapeutic advantage in MRSA biofilm-related infections.\n          <\/jats:p>","DOI":"10.1128\/aac.01236-13","type":"journal-article","created":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T01:58:37Z","timestamp":1376963917000},"page":"5717-5720","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":51,"title":["<i>In Vitro<\/i>\n            Efficacies and Resistance Profiles of Rifampin-Based Combination Regimens for Biofilm-Embedded Methicillin-Resistant Staphylococcus aureus"],"prefix":"10.1128","volume":"57","author":[{"given":"Hung-Jen","family":"Tang","sequence":"first","affiliation":[{"name":"Departments of Medicine, Chi Mei Medical Center, Tainan City, Taiwan, Republic of China"},{"name":"Department of Health and Nutrition, Chia Nan University of Pharmacy &amp; Science, Tainan City, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chung","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Research, Chi Mei Medical Center, Tainan City, Taiwan, Republic of China"},{"name":"Institute of Biotechnology, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Chen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Chi Mei Medical Center, Tainan City, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Medical Research, Chi Mei Medical Center, Tainan City, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chung","family":"Lin","sequence":"additional","affiliation":[{"name":"Medical Research, Chi Mei Medical Center, Tainan City, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Chi Mei Medical Center, Tainan City, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Chieh","family":"Weng","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Chi Mei Medical Center, Tainan City, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Liang","family":"Yu","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Chi Mei Medical Center, Tainan City, Taiwan, Republic of China"},{"name":"Medical Research, Chi Mei Medical Center, Tainan City, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsin","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Chi Mei Hospital, Tainan City, Taiwan, Republic of 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