{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:50:42Z","timestamp":1777931442915,"version":"3.51.4"},"reference-count":65,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Amodiaquine is effective for the treatment of\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium vivax<\/jats:named-content>\n            malaria, but there is little information on the pharmacokinetic and pharmacodynamic properties of amodiaquine in pregnant women with malaria. This study evaluated the population pharmacokinetic and pharmacodynamic properties of amodiaquine and its biologically active metabolite, desethylamodiaquine, in pregnant women with\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. vivax<\/jats:named-content>\n            infection and again after delivery. Twenty-seven pregnant women infected with\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. vivax<\/jats:named-content>\n            malaria on the Thai-Myanmar border were treated with amodiaquine monotherapy (10 mg\/kg\/day) once daily for 3 days. Nineteen women, with and without\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. vivax<\/jats:named-content>\n            infections, returned to receive the same amodiaquine dose postpartum. Nonlinear mixed-effects modeling was used to evaluate the population pharmacokinetic and pharmacodynamic properties of amodiaquine and desethylamodiaquine. Amodiaquine plasma concentrations were described accurately by lagged first-order absorption with a two-compartment disposition model followed by a three-compartment disposition of desethylamodiaquine under the assumption of complete\n            <jats:italic>in vivo<\/jats:italic>\n            conversion. Body weight was implemented as an allometric function on all clearance and volume parameters. Amodiaquine clearance decreased linearly with age, and absorption lag time was reduced in pregnant patients. Recurrent malaria infections in pregnant women were modeled with a time-to-event model consisting of a constant-hazard function with an inhibitory effect of desethylamodiaquine. Amodiaquine treatment reduced the risk of recurrent infections from 22.2% to 7.4% at day 35. In conclusion, pregnancy did not have a clinically relevant impact on the pharmacokinetic properties of amodiaquine or desethylamodiaquine. No dose adjustments are required in pregnancy.\n          <\/jats:p>","DOI":"10.1128\/aac.01242-12","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T02:58:44Z","timestamp":1346122724000},"page":"5764-5773","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":49,"title":["Population Pharmacokinetic and Pharmacodynamic Modeling of Amodiaquine and Desethylamodiaquine in Women with Plasmodium vivax Malaria during and after Pregnancy"],"prefix":"10.1128","volume":"56","author":[{"given":"Joel","family":"Tarning","sequence":"first","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palang","family":"Chotsiri","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Jullien","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, INSERM U663, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Saint-Vincent de Paul, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus J.","family":"Rijken","sequence":"additional","affiliation":[{"name":"Shoklo Malaria Research Unit, Mae Sot, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Bergstrand","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireille","family":"Cammas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes, INSERM U663, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Saint-Vincent de Paul, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"McGready","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"},{"name":"Shoklo Malaria Research Unit, Mae Sot, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratap","family":"Singhasivanon","sequence":"additional","affiliation":[{"name":"Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas P. J.","family":"Day","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Nosten","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"},{"name":"Shoklo Malaria Research Unit, Mae Sot, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Lindegardh","sequence":"additional","affiliation":[{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2007.00788.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00673-07"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-008-9094-4"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544100-00001"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2009.02.003"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4075-4083.2004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61494-8"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012299115260"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-009-9112-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(90)90003-W"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/beog.2001.0231"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000221"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70021-X"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.8.2.187"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/522632"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000774"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-007-9064-2"},{"key":"e_1_3_2_19_2","first-page":"867","article-title":"A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma","volume":"877","author":"Hodel EM","year":"2009","unstructured":"HodelEM. 2009. 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