{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:19:21Z","timestamp":1791407961472,"version":"4.3.3"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"University of the Basque Country UPV\/EHU","award":["UFI11\/25"],"award-info":[{"award-number":["UFI11\/25"]}]},{"name":"Gobierno Vasco - Eusko Jaurlaritza","award":["GIC12\/184_IT-788-13"],"award-info":[{"award-number":["GIC12\/184_IT-788-13"]}]},{"name":"Gobierno Vasco - Eusko Jaurlaritza","award":["GIC15\/103_IT-913-16"],"award-info":[{"award-number":["GIC15\/103_IT-913-16"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Saprochaete capitata<\/jats:named-content>\n            , formerly known as\n            <jats:named-content content-type=\"genus-species\">Geotrichum capitatum<\/jats:named-content>\n            , is an emerging fungal pathogen with low susceptibility to echinocandins. Here, we report the nucleotide sequence of the\n            <jats:named-content content-type=\"genus-species\">S. capitata<\/jats:named-content>\n            hot spot 1 region of the\n            <jats:italic>FKS<\/jats:italic>\n            gene (\n            <jats:italic>FKS<\/jats:italic>\n            HS1), which codifies for the catalytic subunit of \u03b2-1,3-\n            <jats:sc>d<\/jats:sc>\n            -glucan synthase, the target of echinocandins. For that purpose, we first designed degenerated oligonucleotide primers derived from conserved flanking regions of the\n            <jats:italic>FKS1<\/jats:italic>\n            HS1 segment of 12 different fungal species. Interestingly, analysis of the translated\n            <jats:italic>FKS<\/jats:italic>\n            HS1 sequences of 12 isolates of\n            <jats:named-content content-type=\"genus-species\">S. capitata<\/jats:named-content>\n            revealed that all of them exhibited the same F-to-L substitution in a position that is highly related to reduced echinocandin susceptibility.\n          <\/jats:p>","DOI":"10.1128\/aac.01246-17","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T18:51:51Z","timestamp":1513018311000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Sequencing of\n            <i>FKS<\/i>\n            Hot Spot 1 from Saprochaete capitata To Search for a Relationship to Reduced Echinocandin Susceptibility"],"prefix":"10.1128","volume":"62","author":[{"given":"In\u00e9s","family":"Arrieta-Aguirre","sequence":"first","affiliation":[{"name":"Department of Nursing, Faculty of Medicine and Nursing, University of the Basque Country UPV\/EHU, Leioa, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Men\u00e9ndez-Manj\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Medicine and Nursing, University of the Basque Country UPV\/EHU, Leioa, Bizkaia, Spain"},{"name":"Department of Immunology, Microbiology and Parasitology, Faculty of Medicine and Nursing, University of the Basque Country UPV\/EHU, Leioa, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Soledad","family":"Cu\u00e9tara","sequence":"additional","affiliation":[{"name":"Microbiology Department, Hospital Severo Ochoa, Legan\u00e9s, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Fern\u00e1ndez de Larrinoa","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, Faculty of Chemistry, University of the Basque Country UPV\/EHU, Donostia, Gipuzkoa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Garc\u00eda-Ruiz","sequence":"additional","affiliation":[{"name":"Hematology Department, Cruces University Hospital, Barakaldo, Bizkaia, Spain"},{"name":"BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Moragues","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Medicine and Nursing, University of the Basque Country UPV\/EHU, Leioa, Bizkaia, Spain"},{"name":"BioCruces Health Research Institute, Barakaldo, Bizkaia, 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