{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T19:15:48Z","timestamp":1694632548974},"reference-count":16,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Activity of simulated cefditoren urinary concentrations was determined against seven\n            <jats:italic>Escherichia coli<\/jats:italic>\n            isolates. Bactericidal activity was obtained from 4 to 24 h against TEM-1 (penicillinase production\/hyperproduction), TEM-34 (IRT-6), and TEM-116 (extended-spectrum beta-lactamase [ESBL]) and from 6 to 8 h against SHV\/TEM-116 (ESBL) but never against SHV\/TEM-1 (ESBL). Extension of bactericidal activity depended on the resistance genotype\/phenotype tested.\n          <\/jats:p>","DOI":"10.1128\/aac.01247-07","type":"journal-article","created":{"date-parts":[[2007,12,27]],"date-time":"2007-12-27T01:25:24Z","timestamp":1198718724000},"page":"1184-1186","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Urine Bactericidal Activity against\n            <i>Escherichia coli<\/i>\n            Isolates Exhibiting Different Resistance Phenotypes\/Genotypes in an In Vitro Pharmacodynamic Model Simulating Urine Concentrations Obtained after Oral Administration of a 400-Milligram Single Dose of Cefditoren-Pivoxil"],"prefix":"10.1128","volume":"52","author":[{"given":"David","family":"Sevillano","sequence":"first","affiliation":[{"name":"Microbiology Department, School of Medicine, Universidad Complutense, Avda. Complutense s\/n, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Microbiology Department, School of Medicine, Universidad Complutense, Avda. Complutense s\/n, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Alou","sequence":"additional","affiliation":[{"name":"Microbiology Department, School of Medicine, Universidad Complutense, Avda. Complutense s\/n, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u0301a-Jose\u0301","family":"Gime\u0301nez","sequence":"additional","affiliation":[{"name":"Microbiology Department, School of Medicine, Universidad Complutense, Avda. Complutense s\/n, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Torrico","sequence":"additional","affiliation":[{"name":"Microbiology Department, School of Medicine, Universidad Complutense, Avda. Complutense s\/n, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Gonza\u0301lez","sequence":"additional","affiliation":[{"name":"Microbiology Department, School of Medicine, Universidad Complutense, Avda. Complutense s\/n, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Cafini","sequence":"additional","affiliation":[{"name":"Microbiology Department, School of Medicine, Universidad Complutense, Avda. Complutense s\/n, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u0301a-Teresa","family":"Relan\u0303o","sequence":"additional","affiliation":[{"name":"Microbiology Department, School of Medicine, Universidad Complutense, Avda. Complutense s\/n, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Coronel","sequence":"additional","affiliation":[{"name":"Scientific Department, Tedec-Meiji Farma S.A., Alcala\u0301 de Henares, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose\u0301","family":"Prieto","sequence":"additional","affiliation":[{"name":"Microbiology Department, School of Medicine, Universidad Complutense, Avda. 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