{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:10:45Z","timestamp":1791292245848,"version":"4.1.0"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Carbapenem resistance in\n                    <jats:italic>Acinetobacter<\/jats:italic>\n                    spp. is an emerging problem in China. We investigated the molecular epidemiology and carbapenemase genes of 221 nonrepetitive imipenem-resistant clinical isolates of\n                    <jats:italic>Acinetobacter<\/jats:italic>\n                    spp. collected from 1999 to 2005 at 11 teaching hospitals in China. Genotyping by pulsed-field gel electrophoresis (PFGE) found 15 PFGE patterns. Of these, one (clone P) was identified at four hospitals in Beijing and another (clone A) at four geographically disparate cities. Most imipenem-resistant isolates exhibited high-level resistance to all \u03b2-lactams and were only susceptible to colistin.\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA-23<\/jats:sub>\n                    -like genes were found in 97.7% of isolates. Sequencing performed on 60 representative isolates confirmed the presence of the\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA-23<\/jats:sub>\n                    carbapenemase gene. Analysis of the genetic context of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA-23<\/jats:sub>\n                    showed the presence of IS\n                    <jats:italic>Aba1<\/jats:italic>\n                    upstream of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA-23<\/jats:sub>\n                    . All of the 187\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    isolates identified by amplified RNA gene restriction analysis carried a\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA-51<\/jats:sub>\n                    -like oxacillinase gene, while this gene was absent from isolates of other species. Sequencing indicated the presence of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA-66<\/jats:sub>\n                    for 18 representative isolates. Seven isolates of one clone (clone T) carried the plasmid-mediated\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA-58<\/jats:sub>\n                    carbapenemase gene, while one isolate of another clone (clone L) carried the\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA-72<\/jats:sub>\n                    carbapenemase gene. Only 1 isolate of clone Q carried the\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>IMP-8<\/jats:sub>\n                    metallo-\u03b2-lactamase gene, located in a class 1 integron. Of 221 isolates, 77.8% carried\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>PER-1<\/jats:sub>\n                    -like genes. Eleven different structures of class 1 integrons were detected, and most integrons carried genes mediating resistance to aminoglycosides, rifampin, and chloramphenicol. These findings indicated clonal spread of imipenem-resistant\n                    <jats:italic>Acinetobacter<\/jats:italic>\n                    spp. and wide dissemination of the OXA-23 carbapenemase in China.\n                  <\/jats:p>","DOI":"10.1128\/aac.01259-06","type":"journal-article","created":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T20:55:20Z","timestamp":1189457720000},"page":"4022-4028","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":125,"title":["Molecular Epidemiology of Clinical Isolates of Carbapenem-Resistant\n                    <i>Acinetobacter<\/i>\n                    spp. from Chinese Hospitals"],"prefix":"10.1128","volume":"51","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjue","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.2.583-588.2001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2004.01016.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki425"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.12.3739-3743.2002"},{"key":"e_1_3_2_6_2","unstructured":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 2006"},{"key":"e_1_3_2_7_2","unstructured":"Performance standards for antimicrobial susceptibility testing; 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