{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:46:37Z","timestamp":1789980397330,"version":"4.0.1"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI111990"],"award-info":[{"award-number":["R01AI111990"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Acinetobacter baumannii<\/jats:named-content>\n            is emerging with resistance to polymyxins. In 24-h time-kill experiments, high-dose ampicillin-sulbactam in combination with meropenem and polymyxin B achieved additivity or synergy against 10\n            <jats:sup>8<\/jats:sup>\n            CFU\/ml of two clinical\n            <jats:named-content content-type=\"genus-species\">A. baumannii<\/jats:named-content>\n            isolates resistant to all three drugs (maximum reductions, 1.6 and 3.1 logs). In a 14-day hollow-fiber infection model, high-dose ampicillin-sulbactam (8\/4 g every 8 h, respectively) in combination with meropenem (2 g every 8 h) and polymyxin B (1.43 mg\/kg of body weight every 12 h with loading dose) resulted in rapid (96 h) eradication of\n            <jats:named-content content-type=\"genus-species\">A. baumannii<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.01268-16","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T02:50:32Z","timestamp":1483584632000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":86,"title":["High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model"],"prefix":"10.1128","volume":"61","author":[{"given":"Justin R.","family":"Lenhard","sequence":"first","affiliation":[{"name":"Laboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics &amp; Life Sciences, Buffalo, New York, USA"},{"name":"School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, New York, USA"},{"name":"California Northstate University College of Pharmacy, Elk Grove, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Laboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics &amp; Life Sciences, Buffalo, New York, USA"},{"name":"School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zackery P.","family":"Bulman","sequence":"additional","affiliation":[{"name":"Laboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics &amp; Life Sciences, Buffalo, New York, USA"},{"name":"School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Tao","sequence":"additional","affiliation":[{"name":"Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visanu","family":"Thamlikitkul","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom S.","family":"Shin","sequence":"additional","affiliation":[{"name":"Catholic University of Daegu, Hayang, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Nation","sequence":"additional","affiliation":[{"name":"Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen B.","family":"Bulitta","sequence":"additional","affiliation":[{"name":"Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Laboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics &amp; 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