{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:55:48Z","timestamp":1777481748486,"version":"3.51.4"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Although much is known about vancomycin-resistant (VR)\n Enterococcus faecium<\/jats:named-content>\n , little is known about the epidemiology of VR\n Enterococcus faecalis<\/jats:named-content>\n . The predilection of VR\n E. faecalis<\/jats:named-content>\n to transfer the vancomycin resistance determinant to\n Staphylococcus aureus<\/jats:named-content>\n is much greater than that of VR\n E. faecium<\/jats:named-content>\n . The epidemiology of VR\n E. faecalis<\/jats:named-content>\n has important implications regarding the emergence of vancomycin-resistant\n S. aureus<\/jats:named-content>\n (VRSA); 8 of 13 reported VRSA cases have been from Michigan. A retrospective case-case-control study was conducted at the Detroit Medical Center, located in southeastern Michigan. Unique patients with VR\n E. faecalis<\/jats:named-content>\n infection were matched to patients with strains of vancomycin-susceptible (VS)\n E. faecalis<\/jats:named-content>\n and to uninfected controls at a 1:1:1 ratio. Five hundred thirty-two VR\n E. faecalis<\/jats:named-content>\n cases were identified and were matched to 532 VS\n E. faecalis<\/jats:named-content>\n cases and 532 uninfected controls. The overall mean age of the study cohort (\n n<\/jats:italic>\n = 1,596) was 63.0 \u00b1 17.4 years, and 747 (46.8%) individuals were male. Independent predictors for the isolation of VR\n E. faecalis<\/jats:named-content>\n (but not VS\n E. faecalis<\/jats:named-content>\n ) compared to uninfected controls were an age of \u226565 years, nonhome residence, diabetes mellitus, peripheral vascular disease, exposure to cephalosporins and fluoroquinolones in the prior 3 months, and immunosuppressive status. Invasive procedures and\/or surgery, chronic skin ulcers, and indwelling devices were risk factors for both VR\n E. faecalis<\/jats:named-content>\n and VS\n E. faecalis<\/jats:named-content>\n isolation. Cephalosporin and fluoroquinolone exposures were unique, independent predictors for isolation of VR\n E. faecalis<\/jats:named-content>\n . A majority of case patients had VR\n E. faecalis<\/jats:named-content>\n present at the time of admission. Control of VR\n E. faecalis<\/jats:named-content>\n , and ultimately VRSA, will likely require regional efforts focusing on infection prevention and antimicrobial stewardship.\n <\/jats:p>","DOI":"10.1128\/aac.01271-12","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T05:51:17Z","timestamp":1350366677000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Epidemiology of Vancomycin-Resistant Enterococcus faecalis: a Case-Case-Control Study"],"prefix":"10.1128","volume":"57","author":[{"given":"Kayoko","family":"Hayakawa","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dror","family":"Marchaim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Palla","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma Mahesh","family":"Gudur","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harish","family":"Pulluru","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Bathina","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Alshabani","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Govindavarjhulla","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwini","family":"Mallad","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika Reddy","family":"Abbadi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepti","family":"Chowdary","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hari","family":"Kakarlapudi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harish","family":"Guddati","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Das","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveen","family":"Kannekanti","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen","family":"Vemuri","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiv","family":"Doddamani","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkat Ram Rakesh","family":"Mundra","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raviteja Reddy","family":"Guddeti","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Policherla","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarika","family":"Bai","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharan","family":"Lohithaswa","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiva Prasad","family":"Shashidharan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sowmya","family":"Chidurala","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreelatha","family":"Diviti","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna","family":"Sukayogula","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melwin","family":"Joseph","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason M.","family":"Pogue","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R.","family":"Lephart","sequence":"additional","affiliation":[{"name":"Detroit Medical Center University Laboratories, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily T.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Rybak","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"},{"name":"Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith S.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/591861"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.19.2223"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/661599"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir733"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00346-09"},{"key":"e_1_3_2_7_2","unstructured":"Centers for Disease Control and Prevention. 2012. CDC reminds clinical laboratories and healthcare infection preventionists of their role in the search and containment of vancomycin-resistant Staphylococcus aureus (VRSA). Centers for Disease Control and Prevention Atlanta GA. http:\/\/www.cdc.gov\/HAI\/settings\/lab\/vrsa_lab_search_containment.html."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/527392"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00185-10"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02381-08"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.4.686"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.291.6493.432"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1963.03060120024016"},{"key":"e_1_3_2_15_2","volume-title":"Approved standard M100-S19.","author":"Clinical and Laboratory Standards Institute","year":"2009","unstructured":"Clinical and Laboratory Standards Institute. 2009. Performance standards for antimicrobial susceptibility testing; 19th informational supplement. Approved standard M100-S19. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/502550"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0808.010418"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/107662903322541928"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06299-11"},{"key":"e_1_3_2_20_2","unstructured":"Michigan Department of Community Health. 2011. The impact of diabetes in Michigan. The Diabetes Burden Report and the Michigan Diabetes Action plan 2011\u20132014. Michigan Department of Community Health Lansing MI. http:\/\/www.michigan.gov\/documents\/mdch\/2011_Impact_of_Diabetes_365234_7.pdf."},{"key":"e_1_3_2_21_2","volume-title":"Abstr. 51st Intersci. Conf. Antimicrob","author":"Hayakawa K","year":"2011","unstructured":"HayakawaK MarchaimD LephartP PogueJM SunkaraB MoshosJA JagadeeshKK KotraH HasanA SuhrawardyU OsunlanaAM SwanJ PatelS LevineM YeeV AhmadF ReddySML KuK KumarS YerramallaY TiwariN MustaphaM MartinET RybakMJ KayeKS. 2011. Risk factors for co-colonization of vancomycin-resistant Enterococcus faecalis and methicillin-resistant Staphylococcus aureus (MRSA): a multivariate analysis, abstr K-221. Abstr. 51st Intersci. Conf. Antimicrob. Agents Chemother., Chicago, IL."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012283432604"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/428090"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.20.2461"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2006.12.022"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2005.08.015"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01271-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01271-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:28:26Z","timestamp":1645482506000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01271-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1128\/AAC.01271-12"],"URL":"https:\/\/doi.org\/10.1128\/aac.01271-12","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"2012-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}