{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:17:59Z","timestamp":1791865079230,"version":"4.3.4"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The activity of ceftazidime-avibactam was compared with that of ceftazidime alone and meropenem against a collection of 190\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Pseudomonas aeruginosa<\/jats:named-content>\n            clinical isolates recovered from a multicenter study of bloodstream infections. The addition of avibactam increased ceftazidime susceptibility in the complete collection of strains (64.7% to 91.1%) and particularly among subsets of isolates showing AmpC hyperproduction (10.9% to 76.1%) or multidrug resistance (MDR) profiles (27% to 77.8%). The MICs of ceftazidime-avibactam, in contrast with those of ceftazidime or meropenem, remained at \u22644 \u03bcg\/ml for a panel of 16\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">P. aeruginosa<\/jats:named-content>\n            PAO1 isogenic mutants expressing multiple combinations of the most relevant \u03b2-lactam resistance mechanisms.\n          <\/jats:p>","DOI":"10.1128\/aac.01282-16","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T03:04:34Z","timestamp":1470107074000},"page":"6407-6410","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":50,"title":["Activity of Ceftazidime-Avibactam against Clinical and Isogenic Laboratory Pseudomonas aeruginosa Isolates Expressing Combinations of Most Relevant \u03b2-Lactam Resistance Mechanisms"],"prefix":"10.1128","volume":"60","author":[{"given":"Gabriel","family":"Torrens","sequence":"first","affiliation":[{"name":"Servicio de Microbiolog\u00eda and Unidad de Investigaci\u00f3n, Hospital Universitario Son Espases, Instituto de Investigaci\u00f3n Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6452-9945","authenticated-orcid":false,"given":"Gabriel","family":"Cabot","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda and Unidad de Investigaci\u00f3n, Hospital Universitario Son Espases, Instituto de Investigaci\u00f3n Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain A.","family":"Ocampo-Sosa","sequence":"additional","affiliation":[{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"},{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Marqu\u00e9s de Valdecilla-IDIVAL, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Carmen","family":"Conejo","sequence":"additional","affiliation":[{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"},{"name":"Hospital Universitario Virgen Macarena, Instituto de Biom\u00e9dicina de Sevilla (IBiS), Universidad de Sevilla, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Zamorano","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda and Unidad de Investigaci\u00f3n, Hospital Universitario Son Espases, Instituto de Investigaci\u00f3n Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4302-2838","authenticated-orcid":false,"given":"Ferr\u00e1n","family":"Navarro","sequence":"additional","affiliation":[{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"},{"name":"Servicio de Microbiolog\u00eda, Hospital de Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Pascual","sequence":"additional","affiliation":[{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"},{"name":"Hospital Universitario Virgen Macarena, Instituto de Biom\u00e9dicina de Sevilla (IBiS), Universidad de Sevilla, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Mart\u00ednez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"},{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Marqu\u00e9s de Valdecilla-IDIVAL, Santander, Spain"},{"name":"Departamento de Biolog\u00eda Molecular, Universidad de Cantabria, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Oliver","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda and Unidad de Investigaci\u00f3n, Hospital Universitario Son Espases, Instituto de Investigaci\u00f3n Sanitaria de Palma (IdISPa), Palma de Mallorca, Spain"},{"name":"Spanish Network for Research in Infectious Diseases (REIPI), Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00040-09"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr232"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00680-12"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30004-4"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01645-10"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05451-11"},{"key":"e_1_3_1_8_2","volume-title":"CLSI document M100-S26","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2016","unstructured":"Clinical and Laboratory Standards Institute (CLSI). 2016. Performance standards for antimicrobial susceptibility testing, 26th ed. CLSI document M100-S26. 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