{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:41:33Z","timestamp":1787247693890,"version":"build-2736575974"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100006456","name":"Bundesministerium f\u00fcr Wirtschaftliche Zusammenarbeit und Entwicklung","doi-asserted-by":"crossref","award":["21Ac0160"],"award-info":[{"award-number":["21Ac0160"]}],"id":[{"id":"10.13039\/501100006456","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"crossref","award":["21Ac0160"],"award-info":[{"award-number":["21Ac0160"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011099","name":"Deutsche Gesellschaft f\u00fcr Internationale Zusammenarbeit","doi-asserted-by":"crossref","award":["21Ac0160"],"award-info":[{"award-number":["21Ac0160"]}],"id":[{"id":"10.13039\/501100011099","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2024,1,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In 2023, we updated data collected since 2010 on\n            <jats:italic>Plasmodium falciparum K13<\/jats:italic>\n            and\n            <jats:italic>MDR1<\/jats:italic>\n            drug resistance markers in Huye district, southern Rwanda. Artemisinin resistance-associated\n            <jats:italic>PfK13<\/jats:italic>\n            markers occurred in 17.5% of 212 malaria patients (561H, 9.0%; 675V, 5.7%; and 469F, 2.8%), nearly double the frequency from 2019.\n            <jats:italic>PfMDR1<\/jats:italic>\n            N86, linked with lumefantrine tolerance, was close to fixation at 98%. In southern Rwanda, markers signaling resistance to artemisinin and lumefantrine are increasing, albeit at a relatively slow rate.\n          <\/jats:p>","DOI":"10.1128\/aac.01299-23","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T14:04:06Z","timestamp":1702303446000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Escalating\n            <i>Plasmodium falciparum K13<\/i>\n            marker prevalence indicative of artemisinin resistance in southern Rwanda"],"prefix":"10.1128","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3331-3997","authenticated-orcid":false,"given":"Welmoed","family":"van Loon","sequence":"first","affiliation":[{"name":"Charit\u00e9 Center for Global Health, Institute of International Health, Charit\u00e9\u2014Universitaetsmedizin Berlin , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Schallenberg","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Center for Global Health, Institute of International Health, Charit\u00e9\u2014Universitaetsmedizin Berlin , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Igiraneza","sequence":"additional","affiliation":[{"name":"University Teaching Hospital of Butare , Huye, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Habarugira","sequence":"additional","affiliation":[{"name":"University Teaching Hospital of Butare , Huye, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djibril","family":"Mbarushimana","sequence":"additional","affiliation":[{"name":"University Teaching Hospital of Butare , Huye, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Nshimiyimana","sequence":"additional","affiliation":[{"name":"Kabutare District Hospital , Huye, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ngarambe","sequence":"additional","affiliation":[{"name":"University Teaching Hospital of Butare , Huye, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Baptiste","family":"Ntihumbya","sequence":"additional","affiliation":[{"name":"Kabutare District Hospital , Huye, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules Minega","family":"Ndoli","sequence":"additional","affiliation":[{"name":"University Teaching Hospital of Butare , Huye, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank P.","family":"Mockenhaupt","sequence":"additional","affiliation":[{"name":"Charit\u00e9 Center for Global Health, Institute of International Health, Charit\u00e9\u2014Universitaetsmedizin Berlin , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30391-3"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11553"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis747"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0031"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2701.203527"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00142-0"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab352"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2101746"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211803"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-023-01461-4"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-134"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.16-0483"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00901-21"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12876"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1179\/2047773214Y.0000000158"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/650301"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","unstructured":"Zupko RJ Nguyen TD Ngabonziza JCS Kabera M Li H Tran TNA Tran KT Uwimana A Boni MF . 2022. 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