{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:58:43Z","timestamp":1787587123476,"version":"build-2736575974"},"reference-count":7,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Pharmacokinetic data from a randomized, parallel-group, multicenter study are presented. Adults with toenail onychomycosis (\n            <jats:italic>n<\/jats:italic>\n            = 146) received posaconazole (100 mg, 200 mg, or 400 mg) once daily (QD) for 24 weeks or 400 mg QD for 12 weeks. The posaconazole concentration in the great toenail exhibited a dose-related increase starting at week 2 for 24 weeks and a mean toenail-to-plasma concentration ratio of approximately 3:1 at the end of treatment for the 400-mg 24-week dose.\n          <\/jats:p>","DOI":"10.1128\/aac.01302-10","type":"journal-article","created":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T06:10:11Z","timestamp":1310451011000},"page":"4424-4426","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Determination of Posaconazole Levels in Toenails of Adults with Onychomycosis following Oral Treatment with Four Regimens of Posaconazole for 12 or 24 Weeks"],"prefix":"10.1128","volume":"55","author":[{"given":"Gopal","family":"Krishna","sequence":"first","affiliation":[{"name":"Merck Sharp &amp; Dohme Corp., Whitehouse Station, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ma","sequence":"additional","affiliation":[{"name":"Merck Sharp &amp; Dohme Corp., Whitehouse Station, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Martinho","sequence":"additional","affiliation":[{"name":"Merck Sharp &amp; Dohme Corp., Whitehouse Station, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratapa","family":"Prasad","sequence":"additional","affiliation":[{"name":"Merck Sharp &amp; Dohme Corp., Whitehouse Station, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Wahl","sequence":"additional","affiliation":[{"name":"Merck Sharp &amp; Dohme Corp., Whitehouse Station, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Tavakkol","sequence":"additional","affiliation":[{"name":"Merck Sharp &amp; Dohme Corp., Whitehouse Station, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200140060-00005"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb01453.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780410001731583"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01616-09"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1991.tb00405.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2006.06.011"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70102-L"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01302-10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01302-10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:27:17Z","timestamp":1645486037000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01302-10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":7,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1128\/AAC.01302-10"],"URL":"https:\/\/doi.org\/10.1128\/aac.01302-10","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"2010-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-06-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}