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The use of combination therapy has gained much attention in recent years as a possible strategy for overcoming the various shortcomings in the present arsenal. We recently described the effectiveness of tamoxifen in murine models of leishmaniasis, and here, we investigated the interactions between tamoxifen and amphotericin B, one of the most potent drugs used in leishmaniasis treatment. The<jats:italic>in vitro<\/jats:italic>interactions were indifferent for the association of tamoxifen and amphotericin B. The association was also assayed<jats:italic>in vivo<\/jats:italic>in<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Leishmania amazonensis<\/jats:named-content>-infected BALB\/c mice and was found to yield at least additive effects at low doses of both drugs.<\/jats:p>","DOI":"10.1128\/aac.01315-13","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T05:16:41Z","timestamp":1392787001000},"page":"2608-2613","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":64,"title":["Combination Therapy with Tamoxifen and Amphotericin B in Experimental Cutaneous Leishmaniasis"],"prefix":"10.1128","volume":"58","author":[{"given":"Cristiana T.","family":"Trinconi","sequence":"first","affiliation":[{"name":"Departamento de Parasitologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Q.","family":"Reim\u00e3o","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenicer K. 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