{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:10:45Z","timestamp":1761718245087},"reference-count":44,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Polymyxins are old antimicrobials, discontinued for many years because of nephrotoxicity and neurotoxicity reports and reintroduced recently due to the increasing frequency of multiresistant Gram-negative bacterial infections. There are very few data related to toxicity and efficacy from transplanted patients, the major subjects of this study. All solid-organ-transplanted patients from our institution during January 2001 to December 2007 who used polymyxins were retrospectively assessed for nephrotoxicity and treatment efficacy. Microbiological and clinical cure rates were 100% and 77.2%, respectively. Only transplant patients subjected to at least 72 h of intravenous polymyxin were entered in the study. Overall, 92 transplant patients were included, and the nephrotoxicity rate was 32.6%. Multivariate analysis showed a statistically significant association between duration of polymyxin treatment (\n            <jats:italic>P<\/jats:italic>\n            = 0.037; odds ratio [OR], 1.06; 95% confidence interval [CI], 1.00 to 1.12) and significant renal dysfunction. Polymyxin use is associated with very high rates of significant decrease in renal function; therefore, polymyxin must be used only when no other option is available and for as briefly as possible in the solid organ transplant setting.\n          <\/jats:p>","DOI":"10.1128\/aac.01329-12","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T16:08:56Z","timestamp":1357661336000},"page":"1442-1446","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Nephrotoxicity and Efficacy Assessment of Polymyxin Use in 92 Transplant Patients"],"prefix":"10.1128","volume":"57","author":[{"given":"Marcelo M.","family":"Mostardeiro","sequence":"first","affiliation":[{"name":"Solid Organ Transplant Infectious Disease Unit, Infectious Disease Division, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A. P.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Solid Organ Transplant Infectious Disease Unit, Infectious Disease Division, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre R.","family":"Marra","sequence":"additional","affiliation":[{"name":"Solid Organ Transplant Infectious Disease Unit, Infectious Disease Division, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose O. M.","family":"Pestana","sequence":"additional","affiliation":[{"name":"Kidney Transplant Unit, Nephrology Division, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Fernando A.","family":"Camargo","sequence":"additional","affiliation":[{"name":"Solid Organ Transplant Infectious Disease Unit, Infectious Disease Division, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.18426"},{"key":"e_1_3_1_3_2","first-page":"558","article-title":"Extensive pseudomonal pneumonia ultimately responding to polymyxin therapy","volume":"100","author":"Lieberson AD","year":"1969","unstructured":"LiebersonAD WinterLW BehnkeRH MartinRR. 1969. Extensive pseudomonal pneumonia ultimately responding to polymyxin therapy. Am. Rev. Respir. Dis. 100:558\u2013564.","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-57-2-214"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90026-X"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00006-08"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03070180019004"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000171920.44809.f0"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-72-6-857"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1965.tb01882.x"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000190423.82154.01"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021744"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2004.01.003"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.06.061"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01964.x"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/374337"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2005.09.004"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.07.008"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc2358"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.8.2659-2662.2003"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00156906"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh369"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/514732"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/379611"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2004.01043.x"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000400132"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/124.4.394"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1973.tb20476.x"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis286"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01733-10"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.5.1766-1770.2003"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1086\/592577"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2011.07.004"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.11.016"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.10.005"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1086\/599225"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.8.3136-3146.2005"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2009.06.028"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M277"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365540903147001"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03070170019004"},{"key":"e_1_3_1_43_2","first-page":"283","article-title":"Intravenous administration of sodium colistimethate in urinary tract infections","volume":"9","author":"Olesen S","year":"1967","unstructured":"OlesenS MadsenPO. 1967. Intravenous administration of sodium colistimethate in urinary tract infections. Curr. Ther. Res. Clin. Exp. 9:283\u2013287.","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1086\/319211"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-5-1"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01329-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01329-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:13:44Z","timestamp":1645481624000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01329-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1128\/AAC.01329-12"],"URL":"https:\/\/doi.org\/10.1128\/aac.01329-12","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"2012-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-01-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}