{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:06:35Z","timestamp":1785859595628,"version":"3.56.0"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The effect of high\n            <jats:italic>N<\/jats:italic>\n            -acetylcysteine (NAC) concentrations (10 and 50 mM) on antibiotic activity against 40 strains of respiratory pathogens was investigated. NAC compromised the activity of carbapenems (of mostly imipenem and, to lesser extents, meropenem and ertapenem) in a dose-dependent fashion. We demonstrated chemical instability of carbapenems in the presence of NAC. With other antibiotics, 10 mM NAC had no major effects, while 50 mM NAC sporadically decreased (ceftriaxone and aminoglycosides) or increased (penicillins) antibiotic activity.\n          <\/jats:p>","DOI":"10.1128\/aac.01334-16","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T17:04:42Z","timestamp":1476205482000},"page":"7513-7517","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Effect of High\n            <i>N<\/i>\n            -Acetylcysteine Concentrations on Antibiotic Activity against a Large Collection of Respiratory Pathogens"],"prefix":"10.1128","volume":"60","author":[{"given":"Giulia","family":"Landini","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnologies, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Di Maggio","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Sergio","sequence":"additional","affiliation":[{"name":"Corporate Respiratory Medical Affairs, Zambon S.p.A., Bresso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Denis","family":"Docquier","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Maria","family":"Rossolini","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, University of Siena, Siena, Italy"},{"name":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"},{"name":"Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy"},{"name":"Don Carlo Gnocchi Foundation, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7999-5140","authenticated-orcid":false,"given":"Lucia","family":"Pallecchi","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, University of Siena, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"962","article-title":"Laboratory and clinical evaluation of the mucolytic properties of acetylcysteine","volume":"96","author":"Hurst GA","year":"1967","unstructured":"Hurst GA, Shaw PB, LeMaistre CA. 1967. Laboratory and clinical evaluation of the mucolytic properties of acetylcysteine. 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