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We show that a combination of nonbactericidal concentration of this drug and lysophosphatidylcholine (LPC) potently inhibits growth of<jats:italic>Salmonella<\/jats:italic>and at least two other Gram-negative bacteria<jats:italic>in vitro<\/jats:italic>. This combination makes bacterial membrane porous and causes degradation of DnaK, the regulator of protein folding. Polymyxin B-LPC combination may be an effective and safer regimen against drug-resistant bacteria.<\/jats:p>","DOI":"10.1128\/aac.01337-20","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T14:23:43Z","timestamp":1601303023000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Lysophosphatidylcholine Potentiates Antibacterial Activity of Polymyxin B"],"prefix":"10.1128","volume":"64","author":[{"given":"Jitender","family":"Yadav","sequence":"first","affiliation":[{"name":"Hybridoma Laboratory, National Institute of Immunology, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Ismaeel","sequence":"additional","affiliation":[{"name":"Hybridoma Laboratory, National Institute of Immunology, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5870-8034","authenticated-orcid":false,"given":"Ayub","family":"Qadri","sequence":"additional","affiliation":[{"name":"Hybridoma Laboratory, National Institute of Immunology, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1179\/2047773215Y.0000000030"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00064-16"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02476-13"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1336"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33319-9"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.16.6383"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.4049\/jimmunol.159.11.5550","article-title":"Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells","volume":"159","author":"Hobbie S","year":"1997","unstructured":"Hobbie S, Chen LM, Davis RJ, Gal\u00e1n JE. 1997. 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