{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:44:40Z","timestamp":1790239480428,"version":"4.1.0"},"reference-count":19,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The kelch 13 (K13) propeller gene is associated with artemisinin resistance. In a previous work, there were no mutations found in 138\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium falciparum<\/jats:named-content>\n                    isolates collected in 2012 and 2013 from patients residing in Dakar, Senegal (M. Torrentino-Madamet et al., Malar J 13:472, 2014,\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1186\/1475-2875-13-472\">http:\/\/dx.doi.org\/10.1186\/1475-2875-13-472<\/jats:ext-link>\n                    ). However, the N554H, Q613H, and V637I mutations were identified in the propeller region of K13 in 92 (5.5%) isolates in 2013 and 2014. There were five polymorphisms identified in the\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Plasmodium<\/jats:named-content>\n                    \/\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Apicomplexa<\/jats:named-content>\n                    -specific domain (K123R, N137S, N142NN\/NNN, T149S, and K189T\/N).\n                  <\/jats:p>","DOI":"10.1128\/aac.01346-15","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T22:34:05Z","timestamp":1445898845000},"page":"624-627","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":55,"title":["Emergence of Mutations in the K13 Propeller Gene of Plasmodium falciparum Isolates from Dakar, Senegal, in 2013-2014"],"prefix":"10.1128","volume":"60","author":[{"given":"Agathe","family":"Boussaroque","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Parasitologie, D\u00e9partement d'Infectiologie de Terrain, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Marseille, France"},{"name":"Aix Marseille Universit\u00e9, Unit\u00e9 de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9caye","family":"Fall","sequence":"additional","affiliation":[{"name":"Laboratoire d'\u00c9tude de la Chimiosensibilit\u00e9 du Paludisme, F\u00e9d\u00e9ration des Laboratoires, H\u00f4pital Principal de Dakar, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marylin","family":"Madamet","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, Unit\u00e9 de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France"},{"name":"Equipe R\u00e9sidente de Recherche en Infectiologie Tropicale, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, H\u00f4pital d'Instruction des Arm\u00e9es, Marseille, France"},{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheikhou","family":"Camara","sequence":"additional","affiliation":[{"name":"Service des Urgences, H\u00f4pital Principal de Dakar, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Benoit","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, Unit\u00e9 de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France"},{"name":"Equipe R\u00e9sidente de Recherche en Infectiologie Tropicale, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, H\u00f4pital d'Instruction des Arm\u00e9es, Marseille, France"},{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour","family":"Fall","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Principal de Dakar, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aminata","family":"Nakoulima","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie, H\u00f4pital Principal de Dakar, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Dionne","sequence":"additional","affiliation":[{"name":"Maternit\u00e9 H\u00f4pital Principal de Dakar, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadidiatou Ba","family":"Fall","sequence":"additional","affiliation":[{"name":"Service de Pathologie Infectieuse, H\u00f4pital Principal de Dakar, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bakary","family":"Diatta","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dicale, H\u00f4pital Principal de Dakar, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaya","family":"Di\u00e9m\u00e9","sequence":"additional","affiliation":[{"name":"Laboratoire d'\u00c9tude de la Chimiosensibilit\u00e9 du Paludisme, F\u00e9d\u00e9ration des Laboratoires, H\u00f4pital Principal de Dakar, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boubacar","family":"Wade","sequence":"additional","affiliation":[{"name":"Chefferie, H\u00f4pital Principal de Dakar, Dakar, Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pradines","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Parasitologie, D\u00e9partement d'Infectiologie de Terrain, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, Marseille, France"},{"name":"Aix Marseille Universit\u00e9, Unit\u00e9 de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France"},{"name":"Laboratoire d'\u00c9tude de la Chimiosensibilit\u00e9 du Paludisme, F\u00e9d\u00e9ration des Laboratoires, H\u00f4pital Principal de Dakar, Dakar, Senegal"},{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme, Marseille, 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polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa","volume":"211","author":"Kamau E","year":"2015","unstructured":"Kamau E, Campino S, Amenga-Etego L, Drury E, Ishengoma D, Johnson K, Mumba D, Kekre M, William Y, Mead D, Bouyou-Akotet M, Apinjoh T, Golassa L, Randrianarivelojosia M, Andagalu B, Maiga-Ascofare O, Amambua-Ngwa A, Tindana P, Ghansah A, McInnis B, Kwiatkowski D, Djimde AA. 2015. K13-propeller polymorphisms in Plasmodium falciparum parasites from sub-Saharan Africa. 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