{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T23:09:39Z","timestamp":1777158579887,"version":"3.51.4"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"MicuRx Pharmaceuticals, Inc"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2024,11,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              <jats:italic>Mycobacterium abscessus (Mab<\/jats:italic>\n              ) is an opportunistic pathogen common in patients with lung comorbidities and immunosuppression. There are no FDA-approved treatments, and current treatment has a failure rate exceeding 50%. The intravenous oxaborole MRX-6038 is active against\n              <jats:italic>Mab<\/jats:italic>\n              . This study evaluated MRX-5, the oral prodrug, against five\n              <jats:italic>Mab<\/jats:italic>\n              isolates in a mouse lung infection model. MRX-5 showed dose-dependent efficacy, with 15 and 45 mg\/kg doses comparable to the standard of care, supporting progression to clinical trial.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.01351-24","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T13:00:11Z","timestamp":1727960411000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Oral oxaborole MRX-5 exhibits efficacy against pulmonary\n            <i>Mycobacterium abscessus<\/i>\n            in mouse"],"prefix":"10.1128","volume":"68","author":[{"given":"Binayak","family":"Rimal","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth A.","family":"Howe","sequence":"additional","affiliation":[{"name":"Division 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