{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:05:22Z","timestamp":1788174322893,"version":"build-2803163510"},"reference-count":13,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"The National Key Research and Development Program of China","award":["2016YFD0501300"],"award-info":[{"award-number":["2016YFD0501300"]}]},{"name":"The Program for Innovative Research Team in the University of Ministry of Education of China","award":["IRT_17R39"],"award-info":[{"award-number":["IRT_17R39"]}]},{"name":"The Foundation for Innovation and Strengthening School Project of Guangdong, China","award":["2016KCXTD010"],"award-info":[{"award-number":["2016KCXTD010"]}]},{"name":"The Guangdong Special Support Program Innovation Team","award":["2019BT02N054"],"award-info":[{"award-number":["2019BT02N054"]}]},{"name":"The Innovation Team Project of Guangdong University","award":["2019KCXTD001"],"award-info":[{"award-number":["2019KCXTD001"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,11,17]]},"abstract":"<jats:p>\n            We determined\n            <jats:italic>in vivo<\/jats:italic>\n            efficacy and target PK\/PD exposures of antofloxacin against\n            <jats:named-content content-type=\"genus-species\">Streptococcus pneumoniae<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            in the murine pneumonia model. The mean plasma free drug area under the concentration-time curve\/MIC (\n            <jats:italic>f<\/jats:italic>\n            AUC\/MIC) targets associated with stasis and 1-log\n            <jats:sub>10<\/jats:sub>\n            and 2-log\n            <jats:sub>10<\/jats:sub>\n            kill effects were 8.93, 19.2, and 48.1, respectively, for\n            <jats:named-content content-type=\"genus-species\">S. pneumoniae<\/jats:named-content>\n            , whereas they were 30.\n          <\/jats:p>","DOI":"10.1128\/aac.01354-20","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T14:02:36Z","timestamp":1599746556000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["<i>In Vivo<\/i>\n            Pharmacodynamic Target Assessment of Antofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a Neutropenic Murine Pneumonia Model"],"prefix":"10.1128","volume":"64","author":[{"given":"Yu-Feng","family":"Zhou","sequence":"first","affiliation":[{"name":"National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-He","family":"Dai","sequence":"additional","affiliation":[{"name":"National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4209-7555","authenticated-orcid":false,"given":"Jian","family":"Sun","sequence":"additional","affiliation":[{"name":"National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China"},{"name":"Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and Zoonosis, Yangzhou University, Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4654-5837","authenticated-orcid":false,"given":"Xiao-Ping","family":"Liao","sequence":"additional","affiliation":[{"name":"National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800201"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02368-16"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.08.012"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00647-16"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02691-16"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000317581"},{"key":"e_1_3_2_8_2","volume-title":"CLSI standard M07","author":"CLSI","year":"2018","unstructured":"CLSI. 2018. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 11th ed. CLSI standard M07. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"11"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01281-17"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky129"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.10.2793-2797.2001"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.9.2749-2755.2003"},{"key":"e_1_3_2_13_2","first-page":"242","article-title":"Pharmacokinetic study of single and multiple oral dose administration of antofloxacin hydrochloride in healthy male volunteers","volume":"124","author":"Lu Y","year":"2011","unstructured":"Lu Y, Kang ZS, Zhu Y, Zhang M, Liu Y, Zhang M, Li TY, Xiao YH. 2011. Pharmacokinetic study of single and multiple oral dose administration of antofloxacin hydrochloride in healthy male volunteers. Chin Med J (Engl) 124:242\u2013245.","journal-title":"Chin Med J (Engl)"},{"key":"e_1_3_2_14_2","first-page":"462","article-title":"A primary study of antofloxacin breakpoints for agar-dilution sensitivity test","volume":"35","author":"Xiao YH","year":"2010","unstructured":"Xiao YH, Li Y, Liu J, Zhong W, Yang WW. 2010. A primary study of antofloxacin breakpoints for agar-dilution sensitivity test. Chin J Antibiot 35:462\u2013468.","journal-title":"Chin J Antibiot"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01354-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01354-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:40:10Z","timestamp":1645479610000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01354-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,11,17]]}},"alternative-id":["10.1128\/AAC.01354-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.01354-20","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,17]]},"assertion":[{"value":"2020-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01354-20"}}