{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:51:15Z","timestamp":1791298275500,"version":"4.1.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n BAL30376 is a triple combination comprising a siderophore monobactam,\n BAL19764<\/jats:ext-link>\n ; a novel bridged monobactam,\n BAL29880<\/jats:ext-link>\n , which specifically inhibits class C \u03b2-lactamases; and clavulanic acid, which inhibits many class A and some class D \u03b2-lactamases. The MIC\n 90<\/jats:sub>\n was \u22644 \u03bcg\/ml (expressed as the concentration of\n BAL19764<\/jats:ext-link>\n ) for most species of the\n Enterobacteriaceae<\/jats:italic>\n family, including strains that produced metallo-\u03b2-lactamases and were resistant to all of the other \u03b2-lactams tested. The MIC\n 90<\/jats:sub>\n for\n Stenotrophomonas maltophilia<\/jats:italic>\n was 2 \u03bcg\/ml, for multidrug-resistant (MDR)\n Pseudomonas aeruginosa<\/jats:italic>\n it was 8 \u03bcg\/ml, and for MDR\n Acinetobacter<\/jats:italic>\n and\n Burkholderia<\/jats:italic>\n spp. it was 16 \u03bcg\/ml. The presence of the class C \u03b2-lactamase inhibitor\n BAL29880<\/jats:ext-link>\n contributed significantly to the activity of\n BAL30376<\/jats:ext-link>\n against strains of\n Citrobacter freundii<\/jats:italic>\n ,\n Enterobacter<\/jats:italic>\n species,\n Serratia marcescens<\/jats:italic>\n , and\n P. aeruginosa<\/jats:italic>\n . The presence of clavulanic acid contributed significantly to the activity against many strains of\n Escherichia coli<\/jats:italic>\n and\n Klebsiella pneumoniae<\/jats:italic>\n that produced class A extended-spectrum \u03b2-lactamases. The activity of\n BAL30376<\/jats:ext-link>\n against strains with metallo-\u03b2-lactamases was largely attributable to the intrinsic stability of the monobactam\n BAL19764<\/jats:ext-link>\n toward these enzymes. Considering its three components,\n BAL30376<\/jats:ext-link>\n was unexpectedly refractory toward the development of stable resistance.\n <\/jats:p>","DOI":"10.1128\/aac.01370-10","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T04:17:52Z","timestamp":1295410672000},"page":"1510-1519","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["In Vitro<\/i>\n and\n In Vivo<\/i>\n Properties of BAL30376, a \u03b2-Lactam and Dual \u03b2-Lactamase Inhibitor Combination with Enhanced Activity against Gram-Negative Bacilli That Express Multiple \u03b2-Lactamases"],"prefix":"10.1128","volume":"55","author":[{"given":"Malcolm G. 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