{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:43:01Z","timestamp":1788388981488,"version":"build-2803163510"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["320030_175585"],"award-info":[{"award-number":["320030_175585"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Lawrence University Excellence in Science Fund"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,2,17]]},"abstract":"<jats:p>\n            The reliance on one drug, praziquantel, to treat the parasitic disease schistosomiasis in millions of people a year shows the need to further develop a pipeline of new drugs to treat this disease. Recently, an antimalarial quinoxaline derivative (MMV007204) from the Medicines for Malaria Venture (MMV) Malaria Box demonstrated promise against\n            <jats:named-content content-type=\"genus-species\">Schistosoma mansoni<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.01370-20","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T14:00:46Z","timestamp":1606831246000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Activities of Quinoxaline, Nitroquinoxaline, and [1,2,4]Triazolo[4,3-a]quinoxaline Analogs of MMV007204 against Schistosoma mansoni"],"prefix":"10.1128","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5657-9715","authenticated-orcid":true,"given":"Stefan L.","family":"Debbert","sequence":"first","affiliation":[{"name":"Department of Chemistry, Lawrence University, Appleton, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikaela J.","family":"Hintz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Lawrence University, Appleton, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Lawrence University, Appleton, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya R.","family":"Earl","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Lawrence University, Appleton, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant E.","family":"Forsythe","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Lawrence University, Appleton, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"H\u00e4berli","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-3521","authenticated-orcid":true,"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61949-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-012-3151-z"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328318978f"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-017-0286-2"},{"key":"e_1_3_3_6_2","first-page":"3531","article-title":"Antimalarials in the treatment of schistosomiasis","volume":"18","author":"Keiser J","year":"2012","unstructured":"Keiser J, Utzinger J. 2012. Antimalarials in the treatment of schistosomiasis. Curr Pharm Des 18:3531\u20133538.","journal-title":"Curr Pharm Des"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062906"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002610"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04463-14"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.11.021"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.11.059"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.06.004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.11.025"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm020310n"},{"key":"e_1_3_3_15_2","first-page":"797","article-title":"Antimycobacterial activity of some 2,3-dianilinoquinoxaline derivatives","volume":"52","author":"Waisser K","year":"1997","unstructured":"Waisser K, Beckert R, Slos\u00e1frek M, Janota J. 1997. Antimycobacterial activity of some 2,3-dianilinoquinoxaline derivatives. Pharmazie 52:797\u2013798.","journal-title":"Pharmazie"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2017.02.002"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt106"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.1.103"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00332-10"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.01.071"},{"key":"e_1_3_3_21_2","first-page":"513","article-title":"In-vitro high anti-amoebic potency of secnidazole and dimetridazole","volume":"2","author":"Mata-C\u00e1rdenas B","year":"1996","unstructured":"Mata-C\u00e1rdenas B, Vargas-Villarreal J, Gonz\u00e1lez-Garza M, Said-Fern\u00e1ndez S. 1996. In-vitro high anti-amoebic potency of secnidazole and dimetridazole. Pharm Pharmacol Commun 2:513\u2013514.","journal-title":"Pharm Pharmacol Commun"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01159-06"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00599"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.09.025"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00170a031"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103656"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm3009184"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(96)00423-1"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2017.05.003"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02741-14"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4436"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3109\/03602538708998299"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2010.491596"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)82103-6"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0101-y"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-005-8694-y"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005942"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01370-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01370-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:50:11Z","timestamp":1645480211000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01370-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2,17]]}},"alternative-id":["10.1128\/AAC.01370-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.01370-20","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"assertion":[{"value":"2020-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01370-20"}}