{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:28:07Z","timestamp":1790616487032,"version":"4.1.0"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100009571","name":"Institut de Veille Sanitaire","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009571","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002738","name":"Assistance Publique - H\u00f4pitaux de Paris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Group B\n                    <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Streptococcus<\/jats:named-content>\n                    (GBS) is the leading cause of neonatal invasive infections and an emerging pathogen in the elderly. Our objectives were to describe the evolution of GBS resistance to antibiotics in France and to investigate the emergence of fluoroquinolone (FQ)-resistant isolates. A total of 8,757 unrelated GBS isolates were collected and tested for antibiotic susceptibility from 2007 to 2014 according to EUCAST recommendations. All isolates were susceptible to penicillin G, amoxicillin, and vancomycin. Resistance to macrolides decreased from 47.0% to 30.0%, whereas high-level resistance to aminoglycosides, especially amikacin, increased from 6.4% to 8.8% and 24 isolates (0.3%) were highly resistant to gentamicin. FQ resistance gradually increased from 0.2% in 2007 (\n                    <jats:italic>n<\/jats:italic>\n                    = 1) to 1.5% in 2014 (\n                    <jats:italic>n<\/jats:italic>\n                    = 18,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01). Capsular polysaccharide (CPS) genotyping, multilocus sequence typing, and sequencing of the quinolone resistance-determining region (QRDR) showed that GBS isolates of sequence type 19 (ST-19) CPS type V were largely overrepresented in FQ-resistant isolates (\n                    <jats:italic>n<\/jats:italic>\n                    = 30, 45.5%). All 30 strains displayed the same QRDR mutations and were often associated with cross-resistance to macrolides (93.3%) and gentamicin (30%). In conclusion, we report the rise of FQ- and aminoglycoside-resistant GBS in France over an 8-year study period, an evolution likely linked to the clonal expansion of ST-19 CPS V-resistant isolates. This study emphasizes the need for a continuous surveillance of GBS epidemiology and antibiotic susceptibility.\n                  <\/jats:p>","DOI":"10.1128\/aac.01374-16","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T13:04:42Z","timestamp":1476191082000},"page":"7424-7430","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["Changing Epidemiology of Group B Streptococcus Susceptibility to Fluoroquinolones and Aminoglycosides in France"],"prefix":"10.1128","volume":"60","author":[{"given":"Constantin","family":"Hays","sequence":"first","affiliation":[{"name":"Service de Bact\u00e9riologie, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris Centre Site Cochin, Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"INSERM U 1016, Institut Cochin, Team \u201cBarriers and Pathogens,\u201d Paris, France"},{"name":"CNRS UMR 8104, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Louis","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris Centre Site Cochin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Plainvert","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris Centre Site Cochin, Paris, France"},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"INSERM U 1016, Institut Cochin, Team \u201cBarriers and Pathogens,\u201d Paris, France"},{"name":"CNRS UMR 8104, Paris, France"},{"name":"Centre National de R\u00e9f\u00e9rence des Streptocoques, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dmytruk","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris Centre Site Cochin, Paris, France"},{"name":"Centre National de R\u00e9f\u00e9rence des Streptocoques, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rald","family":"Touak","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris Centre Site Cochin, Paris, France"},{"name":"Centre National de R\u00e9f\u00e9rence des Streptocoques, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Trieu-Cuot","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de Biologie des Bact\u00e9ries Pathog\u00e8nes \u00e0 Gram Positif, Paris, 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